摘要
目的 探讨急性大出血时及静脉输注6%羟乙基淀粉(6%HES)或单纯复方乳酸钠行 容量复苏后血清S100B蛋白(简称S100B)的变化,评价6%HES对减轻失血性休克时脑神经损害的 作用。方法 实验犬12只,随机分为6%HES治疗组(H组)和复方乳酸钠治疗组(L组),股动脉放 血复制成急性大出血动物模型。在放血造成失血性休克60min后分别静脉输注6%HES和复方乳 酸钠。于放血前(T0),放血完毕后60min(T1),液体治疗后30min(T2)、2h(T3)、4h(T4)抽取静脉 血测定血清S100B含量。结果 放血造成失血性休克后,两组S100B均显著升高(P<0.01);液体 治疗后2h和4h,S100B均比前一时点显著下降(P<0.01);液体治疗后,H组的S100B浓度显著低 于L组(P<0.01)。结论 急性大出血所致的失血性休克可导致血清S100B的急剧升高,提示急性 大出血及失血性休克可能导致中枢神经损害。有效的容量治疗可促使S100B逐步下降。6%HES 容量治疗对减少S100B的释放的效果优于复方乳酸钠。
Objective To determine the change of serum S100B protein during acute massive haemorrhage and the effect of 6% hydroxyethyl starch(6% HES) solution on S100B in dogs.Methods Acute massive haemorrhage model was induced by blood withdrawal in dogs.Twelve dogs were divided randomly into 6% HES group(group H)and lactated Ringers solution(LR)(group L).At 60min after hemorrhage,the dogs were infused with 6% HES or LR.Blood samples were taken before bleeding(T 0),at 60min after bleeding(T 1),30min(T 2),2h(T 3)and 4h(T 4)after fluild resuscitation,and S100B was determined.Results After hemorrhage,the S100B of all dogs was increased significantly(P<0.01).The concentration of S100B in T 3 and T 4 was decreased more obviously than that of T 1 and T 2(P<0.01).S100B was lower in the groups resusicated with 6% HES than that in LR group.Conclusion The concentration of S100B increases significantly in dogs during acute massive haemorrhage,then gradually decreases after fluid resuscitation.But 6% HES infusion can greatly reduce the release of S100B,which is more than LR.
出处
《临床麻醉学杂志》
CAS
CSCD
2005年第1期44-46,共3页
Journal of Clinical Anesthesiology
基金
广西壮族自治区卫生厅科技计划资助课题(桂卫 9576)
