摘要
A clean process with 3 steps for the synthesis of Fluthiacet-methyl as a super effective herbicide is developed.The product was prepared in several patented methods.However, those methods had the disadvantages of using hazardous materials such as thiophosgene, chloroformate, hexahydropyridazine and phosgene.In the present work, the hazardous materials were replaced by safe reagents,for example, thiophosgene by carbon disulfide, chloroformate and phosgene by bis(trichloromethyl) carbonate(BTC) and hexahydropyridazine by hexahydropridazine hydrochloride.Therefore, the process is operationally convenient and safe with little environmental hazard.Furthermore, the total yield (63%) is quite higher than that (39%) reported in literature.The clean process is valuable for manufacturing Fluthiacet methyl in industrial scale.
A clean process with 3 steps for the synthesis of Fluthiacet-methyl as a super effective herbicide is developed. The product was prepared in several patented methods. However, those methods had the disadvantages of using hazardous materials such as thiophosgene, chloroformate, hexahydropyridazine and phosgene. The hazardous materials were replaced by safe reagents, for example, thiophosgene by carbon disulfide, chloroformate and phosgene by bis(trichloromethyl) carbonate (BTC) and hexahydropyridazine by hexahydropridazine hydrochloride. Therefore, the process is operationally convenient and safe with little environmental hazard. Furthermore, the total yield (63%) is quite higher than that (39%) reported in literature. The clean process is valuable for manufacturing Fluthiacet methyl in industrial scale.
出处
《化工学报》
EI
CAS
CSCD
北大核心
2004年第12期2072-2075,共4页
CIESC Journal
基金
浙江省重点科研资助项目 (No 2 0 0 4C2 2 0 0 4)~~
