摘要
目的 :探讨急性严重呼吸道综合征 (SARS)患者临床治愈后Th1/Th2免疫应答优势及其相应细胞因子的变化。方法 :研究对象共分为 4组 ,即SARS患者临床治愈初期 (A组 :2 3人 )与SARS患者有密切接触史的可能隐性感染者 (B组 :37人 )、SARS患者临床治愈晚期 (C组 :2 1人 )和正常对照组 (D组 :2 6人 )。用放免法检测各组体内的血清细胞因子TNF、IL - 1β、IL - 2、IL - 4、IL - 6、IL - 8和IL - 10水平。分析比较各组间的差异。结果 :①SARS患者临床治愈初期 (A组 )的IL - 1β水平低于正常对照 (D组 ) (P <0 0 1) ,其余的细胞因子如TNF、IL - 2、IL - 4、IL - 6、IL - 8和IL - 10则无显著性差异 (P >0 0 5 )。②可能隐性感染者 (B组 )的细胞因子呈多样性变化 ,TNF、IL - 6和IL - 10皆明显高于D组 (P <0 0 1) ,IL - 2和IL - 4则显著低于D组(P <0 0 1) ,、IL - 1β和IL - 8无明显差异 (P >0 0 5 )。③与A组相比 ,SARS患者临床治愈晚期 (C组 )的、IL- 1β水平明显增高 (P <0 0 1) ,其余各种细胞因子水平无显著性差异 (P >0 0 5 ) ,与D组比各种细胞因子皆无显著性差异 (P >0 0 5 )。结论 :SARS患者临床治愈后体内Th1/Th2相应细胞因子逐渐恢复正常 ,但其变化规律仍有待于进一步的探讨。
Objective To explore the Th1/Th2 immuno-response advantage and dynamic changes of the corresponding serum cytokines levels during convalescence in patients with SARS. Methods Serum cytokines (TNF, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10) levels were determined with RIA in ① Group A, SARS patients in early recovery phase, n=23 ② Group B, subjects with history of close contact with SARS patients——possibly latently infected, n=37 ③ Group C, SARS patients in late-recovery phase, n=21) and ④ Group D, controls, n=26). Results ① In Group A, the serum IL-1β levels were significantly lower than those in controls (P<0.01); the levels of other cytokines tested were not much different from those in controls (P>0.05). ② In Group B subjects, serum TNF, IL-6, IL-10 levels signifcicantly lower (P<0.01) than those in the controls (IL-1β and IL-8 levels about the same in Group B and Group D). ③ In Group C, serum IL-1β levels were significantly higher than those in Group A subjects (P<0.01), the other cytokines levels were about the same in these two groups (P>0.05). ④ Cytokines levels in Group C subjects differed little from those in controls (P>0.05). Conclusion The Th1/Th2 corresponding serum cytokines levels approached normal in SARS patients by the late recovery phase, changes during the whole course of disease requiring furthar study.
出处
《放射免疫学杂志》
CAS
2004年第6期436-438,共3页
Journal of Radioimmanology
