摘要
目的 观察老年病人冠脉介入术后血小板活化指标CD62p、CD63 、CD41、CD61的改变 ,并评价红花注射液对冠脉介入术后病人血小板活化状态的影响。方法 2 0 0 1- 0 8～ 2 0 0 4 - 0 4深圳市人民医院 4 5例急性冠脉综合征病人被分为红花治疗组 (30例 )和对照组 (15例 ) ,两组病例在冠脉介入术后次日检测血小板活化指标CD62p、CD63 、CD41、CD61,红花治疗组病人给予红花注射液静脉滴注 ,每日剂量 15～ 2 0mL静脉内滴入 ,疗程共 10～ 14d。疗程结束后两组均复查血小板活化指标CD62p、CD63 、CD41、CD61,并进行治疗前后比较及两组间的比较。结果 经红花注射液治疗后 ,病人的血小板活化指标CD62p、CD63 较治疗前明显下降 ,P <0 0 1,P <0 0 5 ;CD41、CD61较治疗前无明显差异 ,P >0 0 5。红花液治疗后病人血小板活化指标CD62p较常规治疗组明显下降 ,P <0 0 5。结论 红花注射液具有抑制血小板活化的作用 ,在预防和治疗血栓性疾病中有一定的临床价值 ,临床上可用于冠脉介入术后预防和治疗冠脉内的血栓形成。
Objective To observe the serous level of the CD 62p,CD 63,CD 41,CD 61 which indicates the platelet activity of patients treated by carthamin after PTCA.Methods 45 patients with acute coronary syndrome were divided into carthamin group (30 patients) and control group (15 patients).We examined the patient’s blood CD 62p,CD 63,CD 41,CD 61 levels on the second day after the treatment of PTCA in both group.Then the patients in carthamin group received carthamin treatment (15～20ml iv drip per day).We observed the results again after 10～14 days in both groups,and compared the results.Results The patients’ blood CD 62p,CD 63 levels decreased significantly P<0.01,P<0.05,and CD 41,CD 61 level did not change after the treatment of carthamin(P>0.05).The CD 62p level in carthamin group decrerse significantly after the treatment of carthamin (P<0.05).Conclusion Carthamin can inhibit the patients’platelet activity after the treatment by PTCA.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2005年第1期30-32,共3页
Chinese Journal of Practical Internal Medicine
基金
广东省医学科学技术研究基金资助 (项目编号 :A2 0 0 164 7)
