摘要
目的 探讨大肠癌组织中肥大细胞 (MastCell,MC)亚型的变化及其浸润程度与大肠癌临床病理特征和预后的关系。方法 采用免疫组织化学方法对 60例大肠癌根治术手术标本的MC进行检测 ,并探讨MC亚型MCTC和MCT 与大肠癌的组织学类型、浸润深度、淋巴结转移及生存率之间的关系。结果 (1)MCTC和MCT 的数量相对正常组织均明显增加 ,但大肠癌组和正常组的MCTC和MCT 之间的比例无显著性差异 (P >0 .0 5 ) ;(2 )MCTC和MCT 高计数组的肿瘤浸润深度均明显低于低计数组 (P <0 .0 1) ;(3 )MCTC和MCT 高计数组的癌淋巴结转移发生率及癌远处转移发生率均低于低计数组 (P <0 .0 5 ) ;(4 )MCTC和MCT 浸润高计数组 5年生存率 (65 .5 %和 5 9.3 % )明显高于低计数组 5年生存率 (2 5 .8%和 3 3 .3 % ,P <0 .0 1)。结论 大肠癌组织中MC亚型数量增加 ,但其亚型构成比的变化不明显 ;MC浸润的数量与大肠癌的生物学行为有关 ,对大肠癌患者预后评估有较大的参考价值。
Objective To investigate whether mast cells undergo phenotypic changes and the relationship between the mast cell count and clinical outcome or prognosis in colorectal cancer.Methods The mast cell count was determined by immunohistochemical assay in 60 patients with colorectal cancer and the relationship between mast cell subpopulations(MC TC and MC T)and sex,depth of invasion,lymph node metastasis rate,distant metastasis rates and survival rates is investigated.Results ①There was a significant increase in the number of MC TC and MC T in colorectal cancer compared with normal colorectal tissue(P<0.05),no significant differences was found in the ratio of MC TC and MC T between colorectal cancer cases and normal colorectal cases(P>0.05).②Patients with a low MC TC or MC T count had a significantly deeper invasion than those with a high MC TC or MC T count(P<0.01).③The incidences of lymph node metastasis and distant metastasis in patients with a high MC TC or MC T count was significantly lower than those with a low MC TC or MC T count(P<0.05).④ 5-year survival rates in patients with a low MC TC or MC T count(25.8% and 33.3%,respectively) was significantly lower than those with a high mast cell subpopulations count (65.5% and 59.3%,respectively,P<0.01).Conclusion The number of mast cells increases and the ratio of MC TC or MC T does not change in colorectal cancer tissues;There are some relationships between mast cells and colorectal cancer biology,and mast cells is of value to predict the prognosis.
出处
《临床内科杂志》
CAS
2005年第1期28-30,共3页
Journal of Clinical Internal Medicine
基金
湖北省科技厅十五攻关课题 (批号 :2 0 0 2AA30 1C59)
关键词
肥大细胞亚型
大肠癌
预后
Mast cell subpopulations
Colorectal cancer
Prognosis
