摘要
比较分析了嗜肝病毒家族四成员间的全基因核苷酸序列,得出了它们之间的相对进化距离,DHBV 分野最早,GSHV,WHV 次之,HBV 最晚;其进化方式属趋 异性进化.进一步比较各 ORF 的保守性,发现各 ORF 间及同一 ORF 内的不同区域核苷酸发生替换的频率有明显差别;讨论了各 ORF 的特点及意义.
Comparisons of the nucleotide sequences and amino acid sequences were made among various hep-adnaviruses,and the relative evolutional distances were calculated.From the comparison,it was shownthat DHBV,HBV,GSHV and WHV are derived from a common ancestor,and the three mammalianhepatitis B viruses are more homologous to each other than they are to DHBV,indicating that DHBVstarts to evolve on its own earlier than the three other viruses,as do birds compared with mammals.Based on these findings it was proposed that viruses evolved in a fashion parallel to the species they in-fect.From the calculated relative evolutional distances,it was suggested that WHV and GSHV can becategorized in a way similar to the subgroups of HBV.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1993年第3期203-207,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金
关键词
嗜肝病毒家族
分子进化
核苷酸序列
hepadnaviruse
molecular evolution
nucleotide sequence comparison
