摘要
目的探讨同种原位肝移植后复发性丙型肝炎的肝功能变化特点。方法收集50例肝移植后丙型肝炎复发病例(乙型肝炎病毒DNA阴性)的临床资料,分析肝功能指标与肝炎活动程度、肝纤维化程度、肝脂肪变程度、病毒基因型及排斥反应的关系。结果丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)及γ谷氨酰转移酶(γGT)均显著升高,ALT及AST的水平在不同活动程度的复发性丙型肝炎中的差异无统计学意义,但γGT随着肝炎活动程度加剧而明显升高(P<0.01),上述3个指标在不同肝纤维化程度以及肝脂肪变程度间的差异无统计学意义;感染不同HCV基因型者ALT、AST和γGT的差异无统计学意义;合并排斥反应者的ALT、AST和γGT均明显高于无排斥反应者。结论肝移植后复发性丙型肝炎的肝炎活动程度与γGT密切相关;γGT的变化在评价肝移植后复发性丙型肝炎活动程度以及有无排斥反应时具有重要参考价值。
Objective To study the changes of serum liver functions in recurrent hepatitis C ~after liver transplantation.Methods The clinical data of 50 cases of recurrent hepatitis C (~simultaneously negative for serum HBV DNA) after liver transplantation were collected. The relationship between liver function parameters with the HCV RNA genotype, inflammation histological activity, fibrosis stage, steatosis grade and rejection was evaluated. Results ALT, AST and γ-GT were increased in recurrent hepatitis C. Among them, γ-GT was obviously elevated along with the ~aggravation of histological activity (P<~0.01 ). There was no significant difference in the above ~parameters among the different fibrosis stages or steatosis grades. Also no significant difference was found in the above parameters among the different HCV RNA genotypes. The ALT, AST and γ-GT levels in the patients with rejection were significantly higher than those without rejection. Conclusion γ-GT is an important parameter in evaluating inflammation histological activity as well as predicting rejection in recurrent hepatitis C after liver transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2005年第1期11-13,共3页
Chinese Journal of Organ Transplantation
关键词
肝移植
丙型肝炎
复发
肝功能
转氨酶类
Liver transplantation
Hepatitis C
Recurrence
Transaminases
