摘要
击倒抗性 (kdr)是指昆虫和其他节肢动物由于它们的神经系统对DDT和拟除虫菊酯类杀虫剂的敏感性降低而引起的抗性。电压敏感的钠通道是DDT和拟除虫菊酯类杀虫剂的主要靶标。已知拟除虫菊酯是通过改变位于神经膜上的这类通道而发挥其杀虫效果的 ,钠通道基因的点突变是产生kdr抗性的主要原因。 4 0年来kdr抗性一直是重要的研究课题 ,但近 1 0年来在kdr分子生物学方面取得了很大进展。本文主要综述了 1 996年以来所取得的新进展 ,着重于钠通道的结构、在 1 4种害虫中与kdr抗性相关的钠通道基因突变及其氨基酸序列的多态性。
Knockdown resistance (kdr) is used to describe resistance to DDT and pyrethroid insecticides that result from reduced sensitivity of the nervous system in insects and other arthropods. The voltage-sensitive sodium channels are important action targets of DDT and pyrethroids. Pyrethroids are known to exert their insecticidal effects by altering the function of these channels, and the point mutations of their genes are the primary cause for producing kdr resistance. kdr resistance has been the subject of sustained research interest for more than 40 years, but the past decade has witnessed significant advances in the identification of the mechanisms underlying kdr resistance at the molecular level. This paper mainly reviews new advances on molecular biology of kdr resistance obtained since 1996, with emphasis on the structure of voltage-sensitive sodium channel subunit, gene mutations associated with kdr resistance among 14 species of pest arthropods and their amino acid sequence polymorphisms. These results can provide new insight into the mechanisms by which pyrethroids modify the function of voltage sodium channels.
出处
《昆虫学报》
CAS
CSCD
北大核心
2004年第6期830-836,共7页
Acta Entomologica Sinica
基金
国家重点基础发展规划项目 (2 0 0 3CB1 1 44 0 3)
国家自然科学基金项目 (30 2 30 0 72 )
关键词
击倒抗性
电压敏感的钠通道
拟除虫菊酯
基因突变
Knockdown resistance
voltage-sensitive sodium channel
pyrethroid
gene mutations
