摘要
目的:探讨中国北方汉族人肿瘤坏死因子鄄α(TNF鄄α)基因多态性与慢性阻塞性肺疾病(COPD)易感性的关系。方法:应用聚合酶链反应限制性片段长度多态性法(PCR鄄RFLP)检测TNF鄄α基因鄄308位基因型在58例中国北方汉族人COPD患者和60例健康对照者中基因频率的分布。结果:58例COPD患者和60例健康对照者TNF2频率分别为17.5%、7.5%,2者差异有统计学意义(P<0.025,OR=2.56)。结论:TNF鄄α(308)的基因多态性与中国北方汉族人COPD易感性有关。
Objective: To investigate the polymorphism in gene for tumor necrosis factor-α(TNF-α) in relation to the susceptibility to the development of chronic obstructive pulmonary disease(COPD) in Han region in North of China. Method: The genotypes of 58 patients with COPD and 60 healthy control subjects were tested with polymerase chain reaction followed by restriction fragment length polymorphism for TNF-α gene. Result: The TNF-α-308*2 allele was detected in 17.5% of COPD and in 7.5% of control subjects(P<0.025, OR=2.56). Conclusion: Genetic polymorphism in TNF-α-308 is associated with development of COPD in Han nationality of North of China.
出处
《山东大学学报（医学版）》
CAS
2004年第6期711-713,720,共4页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅"十五"攻关项目。
关键词
肺疾病
阻塞性
肿瘤坏死因子
基因
结构
肿瘤
易感性
Lung diseases, obstructive
Tumor necrosis factor
Genes, structural, neoplasm
Susceptibility
