摘要
本文用Ames检测方法,研究了β-胡罗卜素、维生素C、羟乙基倍半锗氧化物和亚硒酸钠对直接诱变剂甲基硝基亚硝基胍(MNNG)诱发TA_(100)菌株回复突变作用的抑制效果。四种阻断剂均有较明显的抗诱变作用(抑制率达60%以上)并呈一定的剂量效应关系,测定其ED_(50)值,并比较了它们的抑制效果,当四种阻断剂小同组合时,二种阻断剂同时作用其抑制率均比单独使用时高,抑制率可达85%,说明各种阻断刺之间有协同作用。
By means of Ames test, effects of β-carotene, vitamin C, selenium and organic germanium on the inhibition of MNNG-induced mutagenesis were investigated. Results showed that all these 4 substances had an obvious effect of antimutagenesis, with an inhibition rate of over 60% in each. There also existed a dose-response relationship between the concentration of any of these inhibitors and the effectiveness of antimutagenesis. When any 2 of them were tested in combination there was a synergistic action on the effect of antimutagenesis. These results provided a scientific basis for the prevention and treatment of human gastric carcinoma with these agents.
出处
《上海第二医科大学学报》
CSCD
1993年第3期202-205,共4页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
β-胡罗卜素
维生素C
抗诱变作用
β-carotene vitamin C selenium germanium antimutagenesis MNNG
