摘要
目的 评价左羟丙哌嗪治疗咳嗽的有效性和安全性。方法 采用随机双盲对照试验的方法 ,将有干咳症状的患者 5 0例随机分为两组 ,治疗组 2 6例患者每次给予左羟丙哌嗪口服液 10mL ,po ,tid ;对照组 2 4例患者每次给予右美沙芬糖浆 10mL ,po ,tid ,均连续用药 5d。结果 治疗组临床有效率 69 5 7% ,对照组 61 90 % ,两组比较差异无显著性 (P >0 0 5 ) ;对重度咳嗽的临床有效率 ,治疗组和对照组分别为 93 3 3 % ,69 2 3 % ,经Ridit分析 ,差异有显著性(P <0 0 5 )。不良反应的发生率分别为 2 3 0 7%和 41 67% ,差异有显著性 (P <0 0 5 )。结论 左羟丙哌嗪对咳嗽的治疗效果确切 ,安全性好。
Objective To evaluate the efficacy and safety of levodropropizine in cough treatment. Methods Fifty patients with non-productive cough were randomly divided into two groups for a double-blind control study.The treatment group received levodropropizine 10 mL, po, tid, and the control group received dextromethorphan 10 mL, po, tid. All the patient were treated for 5 days. Results The clinical effective rates in the treatment group and in the control group were 69.56% and 61.90% , respectively(P>0.05), in severer cough treatment were 93.33% and 69.23%, respectively (P< 0.05).The adverse reaction rates in the treatment group and in the control group were 23.07%and 41.67%, respctively (P>0.05). Conclusion Levodropropizine is safe and effective in cough treatment.
出处
《医药导报》
CAS
2005年第1期23-24,共2页
Herald of Medicine
关键词
左羟丙哌嗪
右美沙芬
咳嗽
Levodropropizine
Dextromethorphan
Cough
