摘要
用核酸电泳法对1983～1987年秋、冬季收集的318份急性腹泻患儿的粪便标本进行了轮状病毒的分子流行病学研究,阳性187份。研究表明,轮状病毒始终是本地区秋、冬季节婴幼儿急性腹泻的病原体。轮状病毒的RNA 电泳型分析提示,5年中本地区一直系长型毒株(笫Ⅱ亚群)为流行的优势株,其中4年同时伴有短型毒株(第Ⅰ亚群)流行。从187份阳性标本中检出差异型21个。4个属短型,17个属长型。每年都有数个电泳型毒株流行,但仅有其中的一个占流行优势。多数毒株仅流行1～2年,但有2个毒株持续4～5年被检出。提示轮状病毒的基因组有一定稳定性。
The nuclear acid electrophoresis typing was applied to 187 rotavirus.specimens obtained from 318 stool samples of children with infantile diarrhea.The study indicates that roatvirusos are the main etiologic agents of acuteinfantile diarrhea in autumn and winter seasons in Qingdao area.Virusesof subgroup Ⅱ were found to be the main etiologic agent from 1983～1987,and viruses of subgroup Ⅰ could also be detected in 4 of the 5 years.21different electrophoretic types of rotavirus were found in children withacute diarrhea during the study.Among them,4 electrophoretic typesbelonged to subgroup Ⅰ and 17 to subgroup Ⅱ.Several electrophoretic typescould be found in each year,but only one of them was the prevailing one.Most of the dominative types persisted only for 1～2 years.In contrast,twoof them lasted for 4～5 years.This result indicates the apparent geneticstability of the rostavirus genome upon transmission.
出处
《青岛医学院学报》
1989年第1期1-4,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
腹泻
轮状病毒
流行病学
婴儿
幼儿
Rotavirus infection
Cross sectional studies
Infant
