摘要
为明确阻塞型睡眠呼吸暂停低通气综合征 (OSAHS)患者清醒及不同睡眠期血中血管活性肠肽 (VIP)质量浓度与睡眠质量之间的关系 ,以 1 2例OSAHS患者为研究对象 ,在桡动脉内留置导管监测血压 ,同步进行夜间多导睡眠仪连续记录 ,并分别于睡前清醒时、非快动眼 (NREM)睡眠期、快动眼 (REM )睡眠期及清晨从桡动脉留置的导管内抽取血标本 ,采用放免分析法检测VIP。结果 :1 )睡前清醒时及清晨血VIP质量浓度与总睡眠时间和记录时间之比(TST/TRT ,睡眠效率 )成正相关 (r =0 .5 91 ,P <0 .0 5 ) ,与醒觉时间和记录时间之比 (Arousal/TRT)成负相关 (r =-0 .5 86,P <0 .0 5 ) ;以睡前清醒时作基础值 ,NREM期血VIP质量浓度的变化与快波睡眠和总睡眠时间之比 (Ⅰ +Ⅱ /TST)成负相关 (r=-0 .65 6,P <0 .0 5 ) ,与快动眼睡眠时间和总睡眠时间之比 (REM/TST)成正相关 (r =0 .70 5 ,P <0 .0 1 ) ,REM期血VIP质量浓度的变化与REM/TST成正相关 (r=0 .60 9,P <0 .0 5 ) ;2 )OSAHS患者清醒与不同睡眠期血中VIP质量浓度与最长呼吸暂停时间和睡眠呼吸暂停指数 (AHI)成正相关 ,与血氧的有关指标无相关性。提示
The aim was to determine the relationship between plasma concentrations of Vasoactive intestinal peptide (VIP) and sleep quality in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Retaining manometric tube in radial artery and polysomnography (PSG) were done synchronously in 12 patients with OSAHS who was diagnosed by whole-night PSG. Blood specimen were extracted before sleep, during NREM sleep and REM sleep and the next morning to detect plasma concentrations of VIP with Radioimmunoassay(RIA) method. Results: 1) The VIP values before sleep and in the morning were positively correlated with sleep efficacy(the ratio of total sleep time to total record time, r=0.591,P<0.05) and negatively with Arousal/TRT(the ratio of time in arousal to total sleep time, r=-0.586,P<0.05);The VIP values before sleep were regarded as baseline, the changes in VIP values in NREM sleep were negatively correlated with the ratio of time in stageⅠ+Ⅱto total sleep time(Ⅰ+Ⅱ/TST,r=-0.656,P<0.05) and positively correlated with the ratio of time in REM sleep to total sleep time(REM/TST,r=0.705,P<0.01) and those in REM sleep were also positively correlated with REM/TST(r=0.609,P<0.05); 2) The VIP values in different period were positively correlated with the longest time of sleep apnea and apnea-hypopnea index(AHI), but not with hypoxia. In conclusion, VIP may be involved in regulating the sleep in patients with OSAHS.
出处
《首都医科大学学报》
CAS
2004年第4期493-496,共4页
Journal of Capital Medical University