摘要
目的 观察特比萘芬对伊曲康唑治疗甲真菌病抵抗及复发或再感染者的疗效 ,为难治性、复发性甲真菌病治疗提供临床经验。方法 我们选取伊曲康唑治疗甲真菌病抵抗 4例及复发或者再感染 13例 ,共 17例门诊患者 ,特比萘芬口服 ,2 5 0mg ,1/d ,连续 12周 ,观察治疗结束时和随访 2 4周的疗效和不良反应。结果治疗结束时真菌学疗效可达 88 2 % ,其中指甲为 10 0 % ,趾甲为 85 7% ,随访 2 4周真菌学治愈率为 10 0 %。治疗结束时临床疗效有效率达 84 2 % ,其中指甲为 6 6 7% ,趾甲为 85 7% ;随访至 2 4周时有效率为 94 1% ,指甲 10 0 % ,趾甲 92 9%。仅 2例出现了轻度的胃部不适、皮肤瘙痒及头痛。结论 特比萘芬对伊曲康唑治疗抵抗及复发或再感染的甲真菌病者疗效好 ,且耐受性好 ,不良反应少 ,安全性高。
Objective To observe the efficacy of terbinafine on tr ea ting patients with itraconazole-resistant, recurrent and reinfected onychomycos is. Methods We selected 17 outpatients with itraconazole-resistant (4cases), resurrent and reinfected (13cases) onychomycosis, whom were treated w ith terbinafine, 250 mg, PO, qd, for 12 weeks consecutively. Then the efficacy a nd side effects of terbinafine were recorded at the end of treatment and 24-wee k follow-up. Results The fungal removal rate of terbinafine at the end of treatment was 88.2%, including 100% for nail, 85.7% for toenail, and t he fungal removal rate of 24-week follow-up was 100%. The effective rate of te rbinafine at the end of treatment was 84.2%, including 66.7% for nail, 85.7% for toenail, and the effective rate of 24-week follow-up was 94.1% (100 for n ail, 92.9% for toenail). 2 of the 17 cases had slight stomach uncomfort, skin itch and headache. Conclusion Terbinafine is efficient for itracona zole-resistant, recurrent and reinfected onychomycosis with good tolerability a nd high safety.
出处
《海军总医院学报》
2004年第4期214-217,共4页
Journal of Naval General Hospital of PLA
关键词
特比萘芬
伊曲康唑
甲真菌病
疗效观察
Terbinafine
Itraconazole
Onychomycosis
Efficacy observe ment
