摘要
目的 :探讨系统性红斑狼疮 (SLE)患者血清泌乳素 (PRL)水平检测的临床意义。方法 :应用免疫放射量度分析法测定了 75例SLE患者与 2 5例健康人血清PRL水平。结果 :SLE患者血清PRL水平明显高于正常对照组 ,且活动期升高更明显 ;高泌乳素血症 (HPRL)发生率为 4 0 % ,伴HPRL的患者肾损害发生率明显高于血清PRL正常者 ;血清PRL水平与SLEDAI评分、抗ds DNA抗体滴度倒数呈正相关 ,与C3呈负相关。结论 :SLE患者血清PRL水平升高与病情活动相关 ,其检测可作为监测狼疮病情活动性的指标之一 ;血清PRL水平升高与肾脏损害相关 ,提示PRL可能在SLE肾损害中起作用。
Objective:To investigate the clinical significance of serum prolactin (PRL) in systemic lupus erythematosu (SLE).Methods:Serum PRL levels were determined by immunoradiometric assay in 75 SLE patients and 25 matched healthy controls.Results:The mean serum PRL levels were significantly higher in SLE patients than those in healthy controls,and it was even higher than those in active SLE patients.Hyperprolactiemia (HPRL) was found in 40% SLE patients.The rate of renal involvement in patients with HPRL was higher than normolprolactinemia patients.Serum PRL levels were positively correlated with SLEDAI and anti da DNA levels,and negatively correlated with serum C3 levels.Conclusion:The results suggest that elevated serum PRL correlates with active disease and renal involvement in SLE which indicates PRL might participate in the pathogenesis and renal involvement of SLE and serum PRL could be a useful marker for disease activity and renal involvement in SLE. [
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2005年第1期73-75,共3页
Chinese Journal of Immunology
关键词
系统性红斑狼疮
泌乳素
血清
Systemic lupus erythematosus
Prolactin
Serum
