摘要
为复制符合中医学发病特点的湿热蕴结胆囊结石模型 ,采用含有不同剂量辛辣、油腻的饲料喂养家兔 ,通过对胆囊胆汁粘滞度、结石形成及胆囊粘膜病理情况进行观察。模型 4组有 2只家兔死亡 ;造模各组胆汁粘滞度均较空白对照组增加 ,模型 2、3、4组增加更为明显 ;模型 2组仅 1只家兔有肉眼可见的结石形成 ,3、4组均有 6只家兔有肉眼可见的结石形成 ,3组均有大量的胆固醇结晶析出 ;模型各组胆囊粘膜病理变化均以炎症性改变为主。上述观察提示使用模型 3组 (饲料配方为普通饲料胆固醇辣椒动物脂肪按 10 0 0 .5 0 .5 1的比例配制 )
In order to copy the Gallstone model of retention of dampness-heat in the interior according with the sickening characteristic of TCM, the author adopted peppery and heavy feed which contained different dosage to raise home rabbits, and observed the pathological status of bile viscosity in gallbladder, forming gallstone and cystic mucosa. Two home rabbits died in Model Four Group, gallbladder mucosa of various model groups were more increasing than blank control group, Model Two, Three, Four group increased more obviously; Only a stone could be seen in one rabbit by eye in Model Two Group, but in Model Three, Four group, there were six home rabbits that formed stones in them. All three groups had separated out much cholesterin crystal; The inflammatory change played a important role in pathological change of cystic mucosa in various model groups. From this observation, we know that the method of Model Three Group was better for copying models.
出处
《湖南中医药导报》
2004年第12期52-53,共2页
Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology
基金
湖南省科技厅资助项目 (编号 :B0 135 )
关键词
胆囊结石
模型
家兔
Gallstone
Model
Home rabbit
