摘要
目的 评价静脉输注奥曲肽对胰十二指肠切除术后胰瘘的预防效果。方法 回顾性分析近 7年来施行的 74例胰十二指肠切除术患者的临床资料 ,其中对照组 3 6例 ,奥曲肽治疗组 (奥曲肽组 ) 3 8例。从手术当日至术后 7d奥曲肽组每天静脉输注奥曲肽 0 .5 μg/(kg·h) ,观察临床症状、体征、腹腔引流情况及胰液的分泌量。结果 奥曲肽组临床胰瘘的发生率、平均住院日以及术后 1,3 ,5d胰液的分泌量均显著低于对照组 ,奥曲肽组停用奥曲肽后胰液的分泌量较停药前显著增加。
Objective To assess the effect of intravenous infusion of octreotide in prevention of pancreatic fistula after pancreaticoduodenectomy. Methods The clinical data of 74 cases of pancreaticoduodenectomy performed from January 1996 to July 2003 were retrospectively reviewed. These included 36 cases in control group in which octreotide was not adminstered,and 38 cases in octreotide group in which octreotide was administered by intravenous infusion of 0.5μg/( kg·h) for 12 hours per day from the operative day to postoperative day 7. The study parameters included clinical manifestation,drainage from peritioned cavity and the amount of drainage of pancreatic fluid. Results The drainage of pancreatic fluid at postoperative day 1,3,5 the in octreotide group was significantly less than those in the control group,the average hospital stay and the incidence of pancreatic fistula were significantly lower than those in the control group,and the drainage of pancreatic fluid was significantly increased after the withdrawal of octreotide in the octreotide group. Conclusions Intravenous infusion of octreotide can significantly lower the incidence of pancreatic fistula after pancreaticoduodenectomy.
出处
《中国普通外科杂志》
CAS
CSCD
2004年第12期927-929,共3页
China Journal of General Surgery
