摘要
目的 应用高分辨力超声评价高血压患者肱动脉内皮功能。方法 研究对象包括 2 4例原发性高血压患者和 18例健康对照者。应用高分辨力超声测量静息状态下、反应性充血试验后、舌下含服硝酸甘油后的肱动脉内径 ,并计算反应性充血试验和硝酸甘油诱发的内径百分变化率。结果 反应性充血试验诱发的肱动脉内径百分变化率高血压患者显著低于健康对照者 [(3 5 9± 2 5 8) %vs (14 31± 4 95 ) % ,P <0 0 0 1],硝酸甘油诱发的肱动脉内径百分变化率高血压患者和健康对照者差别无显著统计学意义 [(17.0 3± 6 .6 7) %vs(2 1.0 0± 6 .94 ) % ,P =0 .0 6 8]。结论 高血压患者肱动脉内皮依赖性舒张功能减低。
Objective To evaluate brachial arte ry endothelial function in patients with hypertension using high-resolution ultrasonography. Methods Measurements of brachial artery diameter were performed by high-resolution ultrasonography during baseline, reactive hyperemia and sublingual nitroglycerin administration in 24 patients with essential hypertension and 18 healthy subjects. The percent change in brachial artery diameter induced by reactive hyperemia and nitroglycerin was calculated. Results The percent change was significantly less in patients with hypertension than in healthy subjects [(3 59±2 58)% vs (14 31±4 95)%, P<0 001]. No significant difference was found in percent change in the brachial artery diameter induced by sublingual nitroglycerin between the patients and the controls [(17.03±6.67)% vs (21.00±6.94)%, P = 0.068] . Conclusion The decreased percent change in the brachial artery diameter induced by reactive hyperemia in patients with hypertension compared with healthy subjects indicates that brachial endothelium-dependent dilation is impaired in patients with hypertension.
出处
《山西医科大学学报》
CAS
2004年第6期576-578,共3页
Journal of Shanxi Medical University
基金
山西省高校科技开发研究资助项目 (2 0 0 3 10 7)
关键词
肱动脉
内皮
血管
充血
反应性
超声检查
高血压
brachial artery
endothelium, vascular
hyperemia, reactive
ultrasonography
hypertension
