摘要
本实验设计从Boc Glu OH ,Boc Asp OH的两个羧基出发 ,最后通过I2 氧化两个半胱氨酸的巯基生成二硫键 ,得到一类新型含二硫键的环肽 ,该环肽通过1HNMR ,MS等确定了其结构 .
Novel disulfide bond-bearing cyclopeptides have been designed and synthesized by iodine oxidation of his (S-Acm) of Boc-Glu-(Leu-Cys-OMe)-Leu-Cys-OMe and Boc-Asp-(Leu-Cys-OMe)-Leu-Cys-OMe in high dilute condition. The reaction products were identified by H-1 NMR and MS spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第12期1629-1632,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金 (Nos.2 0 1 32 0 2 0
2 0 372 0 51 )资助项目
