摘要
骨形态发生蛋白 7是转化生长因子 β (TGF β)超家族中的一员 ,最初因其能促进造骨细胞的分化和诱导异位骨的形成而得名。随着研究的深入 ,发现BMP 7的生物学功能不仅限于其诱导成骨活性 ,而且涉及全身许多器官的发育和形成 ,在骨、肾、肾上腺、膀胱和脑组织以及某些骨肉瘤细胞中都有表达。在许多肾脏疾病模型中 ,可以阻止肾小管间隙纤维化保护肾脏功能。
Bone morphogenetic protein-7, a member of the transforming growth factor-beta (TGF-β) superfamily, initially got the name because it is able to accelerate the osteoblast differentiation and induce new bone formation in ectopic site. Further study showed that the biological functions of BMP-7 are not limited to the ability to induce bone formation, and it is also involved in the growth and formation of other body organs. It is expressed in the bone, kidney, adrenal glands, bladder, brain and cells of patients with some osteogenic sarcoma. In many models of kidney diseases, it can prevent tubulointerstitial fibrosis and protect renal functions. In this article, we review the recent advances in the study of molecular structure, signal transformation and biological function of this protein.
出处
《医学分子生物学杂志》
CAS
CSCD
2004年第6期382-385,共4页
Journal of Medical Molecular Biology
基金
国家高技术研究发展计划(863计划)博士基金(2003AA2Z3532)
潮南市科学技术发展计划项目(招标专项)
关键词
骨形态发生蛋白-7
骨诱导
肾
纤维化
bone morphogenetic protein-7
inducement of bone
renal
fibrosi
