摘要
采用心脏程序刺激方法和单相动作电位记录技术研究静脉注射氯卡胺(2mg/kg)对12例房室折返心动过速患者右室肌复极化过程的影响。每例患者测定给药前后右室肌有效不应期和记录固定右房起搏频率(120ppm)时右室肌单相动作电位。结果显示氯卡胺明显缩短单相动作电位复极化90％、50%间期(MAPD_(90)、MAPD_(50)),加速心室肌复极化过程;心肌有效不应期改变不明显,右室有效不应期与MAPD_(90)比值显著增加,由此提示氯卡胺可增加心肌的膜稳定性。
Effect of intravenous administration of lorcainide on ventricular myocardial repolarization in man was studied with programmed electrical cardiac stimulation and recording techniques of monophasic action potentials (MAP) in 12 patients suffering from atrioventricular reentry tachycardia. Measurments of MAP durations and of the ventricular effective refractory period (VERP) were performed in each patient from the right ventricular apex with constant right atrial paced rhythm(120ppm) before and 20 minutes after the intravenous administration of lorcainide (12mg/kg over 10 minutes). The results showed that lorcainide induced singnificant decrease of MAPD_(90)(9.0%,P<0. 001),MAPD_(50)(6. 1%,P<0. 002) and a significant increase of RV-ERP/MAPD_(90) ratio but no significant changes of RV-ERP. Because lorcainide increased the RV-ERP/MAPD_(90) ratio indicating that this agent may increase the membrance stability of myocardium,this may suggest the clinical efficacy of lorcainide.
关键词
氯卡胺
心室肌复极化
抗心律失常药
Lorcainide
Monophasic action potentials
Ventricular myocardial repolarization
