摘要
目的:为了解脑梗死患者急性期可溶性粘附分子的变化及临床意义。方法:采用双抗体夹心ELIsA法测定76例脑梗死患者血清sICAM-1、sVCAM-1、sE-selectine,并与52例TIA患者和40例健康老年人对照比较。结果:脑梗死患者24小时内血清sICAM-1、sVCAM-1、sE-selectine水平明显高于TIA和健康对照组(P<0.01)。大梗死灶组血清sICAM-1、sVCAM-1、sE-selectine水平明显高于中梗死灶组和小梗死灶组。脑梗死患者血清sICAM-1、sVCAM-1、sE-selectine水平在脑梗死发生24小时至7天呈现上升趋势,7天至14天呈下降趋势。结论:sICAM-1、sVCAM-1、sEselectine与急性脑梗死密切相关,参与了缺血后脑组织损伤的病理过程。在脑梗死急性期阻断粘附分子的表达可能有助于减轻缺血性脑损伤。
Objective: To study the changes of serum Soluble Adhesive Molecules in patients with acute cerebral infarction and its clinical significance. Methods: The levels of serum soluble intercellular adhesive molecule-1 (sICAM-1), soluble vascular cell adhesive molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) were measured serially with two layer antibody sandwich ELISA in 76 patients with acute cerebral infarction, 52 patients with TIA and 40 normal controls. Results: The levels of serum sICAM-1, sVCAM-1 and sE-selectin in patients with cerebral infarction within 24 hours after the onset were higher than that in patients with TIA and normal controls (P<0. 01). The levels of serum sI CAM-1, sVCAM-1 and sE-selectin were higher in the patients with large cerebral infarction than that in patients with medium and small cerebral infarction. The levels of serum sICAM-1. sVCAM-1 and sE-selectin in patients with cerebral infarction increased from 24 hours to 7 days and decreased from 7 days to 14 days. Conclusions: These findings suggest that sICAM-1. sVCAM-1 and sE-selectin are closely related to the development of acute cerebral infarction, and it may play a role in the pathological procedure of cerebral lesions after cerebral ischemia. It may diminish ischemie cerebral lesions to inhibit the expression of adhesive molecules in acute phrase of cerebral infarction.
出处
《脑与神经疾病杂志》
2004年第6期413-415,共3页
Journal of Brain and Nervous Diseases
基金
江苏省卫生厅重点攻关课题(H200217)
