摘要
目的:观察急性期和恢复期脑出血和脑梗死患者血清和脑脊液的神经元特异性烯醇化酶(neuronspecificenolase,NSE)的变化,探讨其与神经功能缺损程度的相关性。方法:分别收集2002-06/2004-06甘肃省人民医院脑系科收治的50例急性期和恢复期脑出血患者、50例急性期和恢复期脑梗死患者及20例正常人的血清、脑脊液标本,采用酶联免疫分析方法测定NSE,并进行统计学分析。结果:脑梗死组急性期血清NSE质量浓度是(26.82±7.03)μg/L,脑脊液NSE质量浓度是(33.28±11.34)μg/L;脑出血组急性期血清NSE质量浓度是(22.44±6.06)μg/L,脑脊液NSE质量浓度是(28.48±8.97)μg/L;并且病情越重、血清和脑脊液中NSE的质量浓度越高。急性期脑出血和脑梗死患者血清和脑脊液中NSE质量浓度呈显著正相关(脑出血组r=0.920,P<0.01;脑梗死组r=0.865,P<0.01);脑出血和脑梗死患者血清和脑脊液中NSE质量浓度与出院时神经功能缺损程度呈显著正相关(脑出血组r=0.893,P<0.01;脑梗死组r=0.736,P<0.01)。结论:血清和脑脊液中NSE的质量浓度能反映脑损害的程度,是判断脑损害程度的定量信息,对预测患者出院后神经症状和体征的恢复程度也具有较大的价值。
AIM:To investigate the changes of neuron specific enolase(NSE) in serum and cerebrospinal fluid(CSF) of patients with cerebral infarction(CI) and cerebral hemorrhage(CH) both in acute and convalescence stage,and its correlation with the degrees of neurologic impairment. METHODS:Samples of serum and CSF were collected from 50 patients with CH and 50 patients with CI both in acute and convalescence stage and 20 normal persons,who were selected from the Department of Brain,People's Hospital of Gansu Province from June 2002 to June 2004.The contents of NSE were assayed by enzyme linked immunoadsordent assay(ELISA) and analyzed statistically. RESULTS:The quality concentrations of NSE both in serum and CSF were(26.82±7.03) μg/L and(33.28±11.34) μg/L in CI group respectively.The quality concentrations of NSE both in serum and CSF were(22.44±6.06) μg/L and(28.48±8.97) μg/L in CH group respectively.The patient's conditions were more serious with the increasing quality concentration of NSE both in serum and CSF.The quality concentrations of NSE both in serum and CSF were positive correlation between the patients with acute CH(r=0.920, P< 0.01) and the patients with acute infarction(r=0.865,P< 0.01).The quality concentration of NSE both in serum and CSF of patients with CH and CI were positive correlation with the degrees of neurologic impairment after discharge(r=0.893,P< 0.01 in CH group;r=0.736,P< 0.01 in CI group). CONCLUSION:The quality concentration of NSE both in serum and CSF can reflect the degrees of brain injury,and is also a quantitive parameter for it.Moreover,it is valuable for the recovery of neural symptom and physical sign of patients after discharge.
出处
《中国临床康复》
CSCD
2004年第34期7716-7718,共3页
Chinese Journal of Clinical Rehabilitation
