摘要
With the sequencing of human genome almost complete, human genome project enters the post-genome-sequencing era. Compared to genomics, the analysis of proteome is rather difficult since in human cells there are around 200000 proteins, which are expressed at any time at different levels of concentration with a wide dynamic range. In addition, a given proteome is not static but dynamic, being defined by a combination of the cell's genome, environment, and even its history. To meet the higher and higher requirements from proteome analysis, in our recent work, we have developed some capillary electrophoresis (CE)-based techniques for the analysis of complex protein samples.
出处
《色谱》
CAS
CSCD
北大核心
2004年第4期377-381,共5页
Chinese Journal of Chromatography
基金
国家重点基础研究发展计划(973计划)，国家自然科学基金，中国科学院"百人计划"
关键词
毛细管电泳
蛋白质
双向电泳
色谱-质谱
capillary electrophoresis
two-dimensional electrophoresis
mass spectrometry
protein analysis
