摘要
本文采用新型接触电极观察三种药物对家族性长QTU综合征患者的早期后除极、U波及室性心律失常的作用,发现维拉帕米及普萘洛尔有效,而利多卡因则无效,并提示早期后除极与本病扭转室速的发病有关．
The electropharmacological evaluation and electrophysiological mechanism in a patient with familial long QTU syndrohie and torsade de pointes (Tdp)Were studied. A rapid ventricular pacing train of 30 stimuli at cycle lengths (CLs ) of 300 and 275ms couldn't induce extrasystoles and Tdp after Ⅳ verapamil and propranolol respectively ;While a pacing train of 30 stimuli at CL 275ms could elicit a series of subsequent ventricular extrasystoles and Tdp after Ⅳ lidocaine. A short-long-short sequence was observed. The ectopic extrasystole caused by a triggered upstroke that arises from an early afterdepolarization (EAD),gives rise to a long pause which can make the appearance of another EAD,thus precipitating the tachycardia. This study shows that the EAD may play a role in the genesis of adrenergic-dependent and pause-dependent Tdp which were electropharmacologically suppressed by Ⅳ verapamil and propranolol,but not by Ⅳ lidocaine.
出处
《临床心电学杂志》
1993年第2期56-59,共4页
Journal of Clinical Electrocardiology
基金
国家自然科学基金
关键词
长QTU综合征
心动过速
电药理学
early afterdepolarization
long QTU syndrome
torsade de pointes
electropharmacology triggered firing
