Study on the Clinical Effectiveness of Thymectomy for Myasthenia Gravis
被引量:1
Study on the Clinical Effectiveness of Thymectomy for Myasthenia Gravis
摘要
Objective To investigate the theoretical basis and clinical significance of thymectomy in the treatment of myasthenia gravis (MG). Methods Analyze the changes in the contents of serum AchRab and sIL-2R, lymphocyte subtypes in peripheral blood lymphocytes before and after thymectomy in 69 patients.Results In the study group significant changes were found in serum contents of AchRab and sIL-2R before and after operation and there was also remarkable change in the number and constitution of peripheral blood lymphocyte subtypes. Conclusion Thymectomy is an effective therapy for MG.
作者
PAN Tiecheng, YAN Hua, ZHANG Ni, PAN Youming, TANG Yingxiong, WEN Xiang, SONG Dingwei, HU Ming, LIU Ligang, LIU Zixiong, YANG Mingshan, XU Jinzhi, PU Bitao, GAO Boting Department of Thoracis Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
参考文献8
-
1Pan Tie-cheng,Chen Qi-fu,Zhang Liang-hua,Shen Yuan-zhong,Xie Zhao-ping,Yang Ming-shan,Bu Bi-tao,Cao Xue-bing.Surgical treatment of myasthenia gravis and evaluation of its efficacy[J].Journal of Tongji Medical University.1991(2) 被引量:1
-
2Inoue M,Okumura M,Miyoshi S,et al.Impaired expression of MHC class Ⅱ molecules in response to interferon-gamma on human thymoma neoplatic epithelia cells[].Clinical and Experimental Immunology.1999 被引量:1
-
3Yoshikawa H,Satoh K,Yasukawa Y,et al.Analysis of immunoglobulin secretion by lymph organs with myasthenia gravis[].Acta Neurologica Scandinavica.2001 被引量:1
-
4Deng C,Goluszko E,Christadoss P.Fas/Fas ligand pathway, apoptosis,and clonal anergy involved in systemic acetylcholine receptor T cell epitope tolerance[].J Immunol.2001 被引量:1
-
5Yoshikawa H,Lennon VA.Acetylcholine receptor autoantibody secretion by thymocytes: relationship to myasthenia gravis[].Neurology.1997 被引量:1
-
6Sempowski G,Thomasch J,Gooding M,et al.Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis[].J Immunol.2001 被引量:1
-
7Tesar V,Jelinkova E,Jirsa M Jr,et al.Soluble adhesion molecules and cytokines in patients with myasthenia gravis treated by plasma exchange[].Blood Purification.2000 被引量:1
-
8Sommer N,Willcox N.Myasthenia thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells[].Annals of Neurology.1990 被引量:1
同被引文献2
-
1郭秀海,吴卫平,石怀银,李向红.胸腺瘤病理分型与重症肌无力关系的研究[J].临床神经病学杂志,2002,15(3):151-153. 被引量:11
-
2薛志强,王如文,蒋耀光,谭群友,赵云平.胸腺瘤患者预后因素分析[J].中国胸心血管外科临床杂志,2003,10(2):98-100. 被引量:13
-
1WU Guo-yong PANG Jing-zhuo CHENG Chao LU Jian-jun MA Jun GU Yong ZHONG Fuo-tian LUO Hong-he.Prognosis of the short-term efficacy of thymectomy for myasthenia gravis with serum protein profiles[J].Chinese Medical Journal,2009(14):1625-1630.
-
2王彦群,李永丽,马希峰,张清勇.重症肌无力患者胸腺切除前后血清AchRab和SIL-2R变化的研究[J].河南外科学杂志,1999,5(4):351-352.
-
3李润智,姜红菊,赵锡江,高建,刘宗亮.重症肌无力的围术期治疗[J].现代医学,2007,35(6):485-486. 被引量:1
-
4蒋耀光,范士志,陈建明,王如文,陈文君.FACTORS RELATED TO LONG-TERM EFFEGTS OF THYMECTOMY ON MY ASTHENIA GRAVIS[J].Chinese Medical Journal,1995(3):41-45. 被引量:1
-
5朱惠民,张旭,陈根强,孙成超,叶好好.血清连接素抗体和胸腺CT对重症肌无力合并胸腺瘤的诊断价值[J].浙江预防医学,2009,21(8):86-87.
-
6代秀珍,曾文慧,谢颂平.胸腺切除术治疗重症肌无力43例的手术疗效及其影响因素分析[J].实用医院临床杂志,2012,9(2):61-63. 被引量:1
-
7王维化,王文凤,国红.胸腺切除治疗重症肌无力189例临床分析[J].实用全科医学,2006,4(3):335-336. 被引量:2
-
8郑智,潘铁成,潘友民,陈涛.心脏瓣膜病合并重症肌无力的外科治疗[J].中华胸心血管外科杂志,2009,25(1):17-17. 被引量:2
-
9曾进,章咏裳,任大洪.The Influence of Thymectomy on Germ-cells of the Testis in Mice[J].Journal of Huazhong University of Science and Technology(Medical Sciences),1995,15(2):112-116.
-
10王勇文,张晋.胸腔镜胸腺扩大切除术治疗重症肌无力30例[J].陕西医学杂志,2015,44(11):1560-1561. 被引量:1