摘要
通过磁共振和形态学研究发现 ,不断积累的轴索损伤是大多数多发性硬化 ( multiple sclerosis,MS)患者进行性功能丧失的病理基础 ,而炎症和慢性脱髓鞘病变可能是轴索横断的原因 ,故将 MS看成一种炎性神经变性疾病的观点对其临床治疗、患者监护以及未来治疗方案都有重要意义。
出处
《中国神经免疫学和神经病学杂志》
CAS
2004年第5期286-289,共4页
Chinese Journal of Neuroimmunology and Neurology
参考文献19
-
1[1]Noseworthy JH, Lucchinetti C, Rodriguez M, et al.Multiple sclerosis[J]. N Engl J Med, 2000,343:938-952. 被引量：1
-
2[2]Griffiths I,Klugmann M,Anderson T, et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin[J]. Science, 1998, 280: 1610-1613. 被引量：1
-
3[3]Yin X,Crawford TO,Griffin JW, et al. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons[J]. J Neurosci, 1998,18:1953-1962. 被引量：1
-
4[4]Jartmar C, Yin X, Trapp BD. Axonal pathology in myelin disorders [J]. J Neurocytol, 1999, 28: 383-395. 被引量：1
-
5[5]Kornek B,Storch MK, Weissert R, et al. Multiple sclerosis and chronic autoimmune encephalomyelitis :a comparative quantitative study of axonal injury in active,inactive, and remyelinated lesions [J]. Am J Pathol, 2000,157: 267-276. 被引量：1
-
6[6]Bitsch A, Schuchardt J, Bunkowski S, et al. Acute axonal injury in multiple sclerosis: correlation with demyelination and inflammation [J]. Brain, 2000,123:1174-1183. 被引量：1
-
7[7]Ohlfeld R. Biotechnological agents for the immunotherapy of multiple sclerosis:principles ,problems and perspectives[J]. Brain, 1997,120: 865-916. 被引量：1
-
8[8]McFarland HF, Frank JA, Albert PS, et al. Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in MS[J]. Ann Neurol, 1992,32:758-766. 被引量：1
-
9[9]Mews I,Bergmann M,Bunkowski S, et al. Oligodendrocyte and axon pathology in clinically silent MS lesions[J]. Mult sclera, 1998,4: 55-62. 被引量：1
-
10[10]Lovas G, szilagyi N, Majtenyi K, et al. Axonal changes in chronic demyelinated cervical spinal cord plaques[J]. Brain, 2000,123:308-317. 被引量：1
同被引文献8
-
1卢德宏,汤国才.多发性硬化的临床病理学[J].实用儿科临床杂志,2005,20(4):293-296. 被引量：8
-
2Polman CH, Reingold SC,Edan G,et al. Diagnostic criteria for multiple sclerosis :2005 revisions to the "McDonald Criteria" [J]. Ann Neurol,2005,58(6) :840. 被引量：1
-
3Scarisbrick LA, Linbo R, Vandell AG, et al. Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration [ J ]. Biol Chem, 2008,389 (6) :739. 被引量：1
-
4Hartung HP, Kieseier BC. The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system [ J ]. J Neuroimmunol,2000,107 ( 2 ) : 140. 被引量：1
-
5Terayama R, Bando Y,Jiang YP,et al. Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis [ J ]. Neurosci Lett,2005,382(1/2) :82. 被引量：1
-
6Hebb AL,Bhan V,Wishart AD, et al. Human kallikrein 6 cerebrospinal levels are elevated in multiple sclerosis[ J ] . Curr Drug Discov Technol,2010,7(2) :137. 被引量：1
-
7Guo MF,Ji N,Ma CG. Immunologic pathogenesis of multiple sclerosis[J]. Neurosci Bu11,2008,24(6) :381. 被引量：1
-
8娄江涛,胡成进.组织型激肽释放酶及相关肽酶在中枢神经系统中的作用[J].生命的化学,2010,30(2):307-310. 被引量：3
-
1余丹,张苏明,蔡毅,吴海荣,曾超胜.复发-缓解型多发性硬化患者脑动脉血流速度观察[J].中国热带医学,2004,4(4):561-561.
-
2赵菊芳,毛玲群,谢江文,杨俊彦,颜政,闻绍云,黄睿.中枢神经系统脱髓鞘病变与复发-缓解型多发性硬化[J].中风与神经疾病杂志,2005,22(3):274-275. 被引量：1
-
3黄德晖,吴卫平,蒲传强,朱克.多发性硬化226例临床分析[J].中国神经免疫学和神经病学杂志,2003,10(3):152-155. 被引量：58
-
4屈新辉,张昆南,龚凌云,高幼奇,吴晓牧.大剂量甲泼尼龙与免疫球蛋白治疗多发性硬化急性期的疗效观察[J].江西医药,2008,43(8):784-787. 被引量：11
-
5杨欣,周春奎,吴江,张昱.我国北方地区多发性硬化164例的临床特点[J].中风与神经疾病杂志,2005,22(5):434-436. 被引量：9
-
6卢林友,黄英文.高血压脑出血开颅血肿清除术70例报告[J].临床神经电生理学杂志,2006,15(4):246-247.
-
7肖剑平,肖志恒,朱沂.多发性硬化的治疗[J].中华神经医学杂志,2005,4(1):106-108. 被引量：3
-
8肖丽华,吴晓牧,张昆南,屈新辉.多发性硬化92例临床分析[J].南昌大学学报（医学版）,2010,50(9):71-73. 被引量：1
-
9房效莉,张进进,吴士文.72例视神经脊髓炎临床特点及实验室检查分析[J].中华灾害救援医学,2015,3(5):264-266.
-
10马培奇.美FDA批准达方吡啶改善多发性硬化病患者的行走能力[J].上海医药,2010,31(3):128-128.
