摘要
AIM: To investigate the association between curative effects of interferon-α and partial human leucocyte antigen (HLA)Ⅱ alleles in chronic viral hepatitis B.METHODS: Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-α for 6 mo. HLA-DRB1, -DQA1, and -DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) method. RESULTS: Frequencies of HLA-DRB1*04(P＜0.025) and HLA-DQA1*0303 (P＜0.01) in non-responders were significantly higher than those in partial and complete responders. Frequencies of HLA-DQAI*0505(P＜0.025) and HLA-DQB1*0301(P＜0.005) in partial and complete responders were significantly higher than those in non-responders.CONCLUSION: Non-response to interferon-α therapy is positively correlated with HLA-DRB1*04 and HLA-DQA1*0303， and negatively correlated with HLA-DQA1*0505 and -DQB1*0301 in patient with chronic viral hepatitis B.HLA Ⅱ genes of the identification alleles provide a method for evaluating outcome of interferon-α treatment.
AIM:To investigate the association between curative effects of interferon-α and partial human leucocyte antigen(HLA) II alleles in chronic viral hepatitis B. METHODS:Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-α for 6 mo.HLA-DRB1,-DQA1,and-DQB1 alleles were detected by polymerase chain reaction-sequence specific primer(PCR-SSP)method. RESULTS:Frequencies of HLA-DRBI~*04(P<0.025)and HLA-DQA1~*0303(P<0.01) in non-responders were significantly higher than those in partial and complete responders.Frequencies of HLA-DQA1~*0505(P<0.025)and HLA-DQB1~*0301(P<0.005)in partial and complete responders were significantly higher than those in non- responders. CONCLUSION:Non-response to interferon-α therapy is positively correlated with HLA-DRB1~*04 and HLA- DQA1~*0303,and negatively correlated with HLA-DQA1~*0505 and-DQB1~*0301 in patient with chronic viral hepatitis B. HLA II genes of the identification alleles provide a method for evaluating outcome of interferon-α treatment.
基金
Supported by the Foundation of Shanghai Municipal Health Bureau,No.01444
