摘要
本实验用卵巢癌腹水提纯的免疫抑制性酸性蛋白(IAP)制备的单克隆抗体MI_1和MI_2,对33例卵巢上皮性癌进行免疫组化研究,结果表明,两株抗体的阳性着染率与卵巢癌的类型及病理分级关系不显著,但通过临床随访发现阳性着染程度似与临床分期及预后密切相关。这对于临床上判断预后、估计复发及指导治疗等有一定的意义。此外,MI_2识别的I AP的亚型,似主要由癌细胞产生,考虑有可能作为诊断卵巢癌的一种标志物。
Immunosuppressive Acidic Protein (IAP) monoclonal antibodies MI1 andMI 2 prepared from ascitic fluid of patients with ovarian cancer were utilized in the immuno-histochemical studies on 33 patients with ovarian cancers of epithilial type. No significant relationship in reaction was observed both for the types and the pathological staging of the tumor. However, through follow-up studies, a close correlation seemed to be existed between the intensity of staining and the clinical staging and prognosis of the disease. This test might be of value for clinical judgement of prognosis, estimation of the progression of the disease and to help monitoring during therapy.The MI2 recognizable IAP seemed to be produced within the tumor cells, and might it be possibly to serve as a marker for. identifying ovarian malignancies remained for further investigation.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第1期21-24,共4页
Chinese Journal of Cancer
