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老年严重急性呼吸综合征患者免疫学指标的研究 被引量:1

Comparison of immunologic index differences of SARS patients at old age
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摘要 目的 探讨老年严重急性呼吸综合征 (SARS)患者免疫学指标变化的特点 ,为进一步认识SARS免疫学特点提供依据。 方法 将患者按年龄分为少年儿童组 (<1 8岁 )、中青年组 (1 8~5 9岁 )、老年组 (≥ 6 0岁 ) ,统计各组发病后 5周内各组白细胞、淋巴细胞、T淋巴细胞亚群 (CD3、CD4、CD8)、血沉 (ESR)、C反应蛋白 (CRP)等免疫学指标数据 ,数值以中位数、最小值、最大值表示。比较 3组SARS患者各免疫指标的异同。 结果 发病第 1、2周 ,白细胞计数在不同年龄组间〔3组分别为(6 37和 6 93)、5 32和 8 49、6 1 2和 7 73)× 1 0 9/L〕差异有显著性 ,以中青年组升高趋势最明显。发病后 5周 ,3组间淋巴细胞计数 (分别为 2 41、1 85、1 38× 1 0 9/L)差异有显著性 (P <0 0 0 1 ) ;3组患者淋巴细胞亚群CD3、CD4、CD8细胞计数有各自变化的规律 ,但均在第 4周出现差异有显著性 (P<0 0 5 ,3组CD3分别为 2 32 6 2 0、1 0 95 6 2及 84 8 2× 1 0 6/L ,CD4分别为 1 1 0 6 6 0、6 4 7 99及 4 0 9 44× 1 0 6/L ,CD8分别为 1 0 39 40、4 6 7 88及 379 41× 1 0 6/L)。CRP在第 2周时 3组间 (37 5 1、2 2 5 1及4 6 2 3× 1 0 -2 g/L)差异有显著性 (P <0 0 5 )。 结论 SARS患者外周血T淋巴细胞亚群计数显著? Objective To study the changes of immunologic index characters of the old SARS patients and to reach the deeper realization of them. Methods Totally 1291 SARS patients were divided into three age groups ,then doing statistics of the five weeks' data after the onset of the illness, including WBC、LC、CD3、CD4、CD8、ESR、CRP etc, in order to compare and analyze the difference of three age groups data with Chi square test. Results WBC count of three age groups displayed a significant difference at the first & second week, especially in the young and middle age group. Lymphocyte percentage in WBC showed a significant difference among child group, middle young age group and old age group( P <0 01). During the whole course of disease, there were respective change laws in CD4, CD8 and CD3 for the three age groups, but all changes appeared statistical difference only at the fourth week. ESR level of three age groups SARS patients had no statistics difference. CRP level had a significant statistical difference at the second week in three age groups ( P <0 05). Conclusions A significant descent of T lymphocyte subgroup count shows the immune systems of SARS patients are impaired, and it seems that cellular immune system is the main target tissue. The impairment is mild in child group, and worst in old age group.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2004年第11期789-792,共4页 Chinese Journal of Geriatrics
基金 国家SARS科技攻关重大项目 国家863课题( 2003AA208107) 北京市卫生局资助
关键词 老年人 急性呼吸综合征 免疫学 SARS 淋巴细胞 CD3 CD8 CD4 CRP Respiratory distress syndrome in old age group Lymphocyte
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