摘要
目的探索应用新材料、新方法治疗股骨头坏死防止股骨头塌陷的一种新的治疗方法.方法活门法(Trap-door)建立犬股骨头坏死骨缺损模型.通过活门A组植入股骨头内支撑器/rhBMP-2/自体松质骨;B组植入rhBMP-2/自体松质骨;C组植入自体松质骨.通过组织学、影像学、生物力学观察评价对股骨头坏死骨缺损的修复以及防止股骨头塌陷的效果.结果各组均未出现关节脱位、关节间隙正常.A组缺损区修复,无关节软骨塌陷;B组骨缺损区修复,但骨密度低于周围骨组织;C组仅缺损区周围少量低密度骨形成.A组组织学无软骨塌陷,内支撑器周围新生骨组织包绕,与周围骨组织融合;B组2例软骨塌陷(1.2 mm、1.5 mm),活门区软骨色泽近与正常;C组活门区软骨塌陷(1.8～5.2 mm),色泽苍白,质软易碎.力学测试A组修复区抗压强度明显强于B、C组(P＜0.05).结论应用股骨头内支撑器/rhBMP-2/自体松质骨修复股骨头坏死骨缺损可以加快修复速度,并且恢复股骨头力学强度防止股骨头塌陷.
Objective To explore a new method using new material and technology to repair the defect of osteonecrosis of the femoral head and prevent collapse. Methods In this experiment, the canines divided into three groups randomly. Group A, the defects were implanted into Titanium cage/autocancellous graft/rhBMP - 2; Group B, implanted into autocancellous/rhBMP - 2; Group C, implanted into autocancellous only. Roentgenographic and histological examinations were performed at various time after implantation. Finally, biomechanical test was applied. Results No hip joint dislocation occurred. The defects of the group A and B were repaired completely and titanium cage of group A were combined with new bone . Group C, however, only had little new bone formed. Group B, the new bone formation were more and earlier than group C. No cartilage collapsed in group A, group B and group C the cartilages collapsed 1. 2-5. 2mm respectively. Biomechanical properities of repaired areas of group A were higher than group B and C (P<0.05). Conclusion Titanium cage/autocancellous graft/rhBMP - 2 not only can repair the defects but also can restore the biomechanical properities of osteonecrosis of femoral head.
出处
《骨与关节损伤杂志》
2004年第10期682-685,共4页
The Journal of Bone and Joint Injury
