摘要
感染性休克是多种病原体引起 ,以革兰阴性菌为主介导的一组严重的临床综合征 ,其病死率很高。Toll样受体 (TLR)是免疫细胞膜上的病原体识别受体 ,在介导病原体识别、信号转导、免疫反应的激活中起关键作用。在疾病早期 ,TLR表达增强的细胞对病原体高度敏感 ,通过上调肿瘤坏死因子等细胞因子的表达 ,增强炎症反应杀伤病原体。然而 ,过高的促炎反应将造成组织器官的损害。
Septic shock, a severe clinic syndrome, is induce d by a several of pat hogens, especially gram-negative bacteria, of which the mortality is still hi gh. Toll-like receptors (TLR), pathogen-recognized receptors, are located on su rfac e of innate immune cells. TLRs play an important role in identifying pathogen, transferring signals and activating immune response. During signal transduction , TLRs activate NFκB, upregulate cytokines, such as TNF and IL-1, and enhanc e in flammatory response which kill the pathogens. However, hyper-responses of infl ammation result in organs injury.
出处
《南京铁道医学院学报》
2004年第6期422-426,共5页
Journal of Nanjing Railway Medical College
基金
江苏省卫生厅资助项目 (TS 990 4 )
南京市医学卫生专项基金 (ZGG1 999)
