摘要
目的比较甲基莲心碱体外对三种不同蒽环类抗肿瘤药物的化疗增敏作用。方法利用MTT法观察甲基莲心碱合用表阿霉素或柔红霉素或吡喃阿霉素处理K562/A02细胞后细胞增殖的变化。结果吡喃阿霉素合用甲基莲心碱处理细胞后,与同浓度的表阿霉素或柔红霉素合用甲基莲心碱比较,前者对K562/A02细胞的抑制率明显高于后者(P<0.01)。结论甲基莲心碱对三种不同的蒽环类抗肿瘤药物均具有化疗增敏作用,而甲基莲心碱能更好地增强吡喃阿霉素对K562/A02细胞的抗肿瘤作用。
Objective: To compare the chemosensitive effect of neferine on three kinds of anthracycline antineoplastic drugs in K562/A02 cell line in vitro. Methods: MTT method was used to observe the alteration of the proliferation of K562/A02 cell line treated with 30 μg/ml Epirubicin or Daunorubicin or Pirarubicin combined with Neferine. Results: The inhibiting rate on K562/A02 cell line of Pirarubicin combined with Neferine was significantly higher than that of Epirubicin or Daunorubicin combined with Neferine (P <0.01). Conclusion: Neferine has the chemosensitive effect on the three kinds of anthracycline antineoplastic drugs. However, Neferine can enhance the antineoplastic effect of Pirarubicin better than that of Epirubicin or Daunorubicin in K562/A02 cell significantly.
出处
《中国医学工程》
2004年第5期29-30,37,共3页
China Medical Engineering
