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Synthesis and Anti-influenza Virus Activity of Ethyl 6-Bromo-5-hydroxyindole-3-carboxylate Derivatives

Synthesis and Anti-influenza Virus Activity of Ethyl 6-Bromo-5-hydroxyindole-3-carboxylate Derivatives
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摘要 A series of ethyl 6-bromo-5-hydroxyindole-3-carboxylate derivatives were synthesized and their in vitro anti-influenza virus activity was evaluated. All the compounds were characterized by 1H NMR and MS. A series of ethyl 6-bromo-5-hydroxyindole-3-carboxylate derivatives were synthesized and their in vitro anti-influenza virus activity was evaluated. All the compounds were characterized by 1H NMR and MS.
作者 YanFangZHAO JinHuaDONG PingGONG
机构地区 ShenyangPharmaceuticalUniversity
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第9期1039-1042,共4页 中国化学快报（英文版）
关键词 Ethyl 6-bromo-5-hydroxyindole-3-carboxylate derivatives synthesis anti-influenza virus activity. Ethyl 6-bromo-5-hydroxyindole-3-carboxylate derivatives, synthesis, anti-influenza virus activity.
分类号 TQ465 [化学工程—制药化工] R978.7 [医药卫生—药品]
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  • 1[1]I. D. Gust, A. W. Hampson, D. Lavanchy, Rev. Med. Virol., 2001, 11, 59. 被引量：1
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  • 7[7]Melting points were determined with capillary tube method, and the thermometer was uncorrected. Mass spectra were obtained with a Finnigan LCQ HPLC-MS instrument. 1H NMR spectra were run on a Bruker ARX-300 instrument and the solvents were DMSO-d6.Ⅷa: [MH+] (m/z): 514.1 (Br=79), 516.0 (Br=81); 1H NMR: δppm: 1.07 ( t, 3 H, J=7.2 Hz ), 2.33 ( s, 3 H ), 3.71 ( s, 3 H ), 3.99 ( q, 2 H, J=7.2 Hz ), 4.65 ( s, 2 H ), 5.52 ( s, 2 H ), 6.27 ( s, 1 H ), 6.52 ( s, 1 H ), 7.29 ( m, 5 H ), 7.88 ( s, 1 H ), 8.95 ( br s, 1 H ); Ⅷb: [MH+] (m/z): 517.1 (Br=79), 519.1 (Br=81); 1H NMR: δppm: 0.98 ( m, 2 H ), 1.13 ( m, 2 H ), 1.23 ( t, 3 H, J=7.2 Hz), 2.91 ( s, 1 H), 4.19 ( q, 2 H, J=7.2 Hz ), 4.51 ( d, 2 H, J=5.3 Hz ), 4.73 ( s, 2 H ), 6.60 ( s, 2 H ), 6.93 ( s, 1 H ), 7.36 ( m, 5 H ), 7.53 ( s, 1 H ), 13.13 ( br, 1 H ); Ⅷc: [MH+] (m/z): 491.0 ( Br=79 ), 493.0 ( Br=81 ); 1H NMR: δppm: 1.23 ( t, 3 H, J=7.2 Hz ), 3.51 ( s, 3 H ), 4.17 ( q, 2 H, J=7.2 Hz ), 4.55 ( d, 2 H, J=5.2 Hz ), 4.65 ( s, 2 H ), 6.62 (s, 2 H ), 6.93 ( s, 1 H ), 7.28～7.39 ( m, 5 H ), 7.48 ( s, 1 H ); Ⅷd: [MH+] (m/z): 500.0 (Br=79), 502.0 (Br=81); 1H NMR: δppm: 1.28 ( t, 3 H, J=7.2 Hz ), 3.61 ( s, 3 H ), 4.17 ( q, 2 H, J=7.2 Hz ), 4.54 ( s, 2 H ), 6.01 ( s, 2 H ), 7.09 ( s, 1 H ), 7.19 ( s, 1 H ), 7.27-7.35 ( m, 6 H ), 7.53 ( s, 1 H ), 8.02 ( br s, 1 H ); Ⅷe: [MH+] (m/z): 527.0 (Br=79), 529.0 (Br=81); 1H NMR: δppm: 1.22 ( t, 3 H, J=7.1 Hz ), 3.54 ( s, 3 H ), 4.16 ( q, 2 H, J=7.1 Hz ), 4.52 ( s, 2 H ), 4.66 ( s, 2 H ), 6.89 ( m, 4 H ), 6.89 ( s, 1 H ), 7.18 ( m, 1 H ), 7.39 ( m, 1 H ), 7.43 ( s, 1 H ), 7.45 ( m, 1 H ), 13.12 ( br s, 1 H ); Ⅷf: [MH+] (m/z): 550.0 (Br=79), 552.0 (Br=81); 1H NMR: δppm: 1.06 ( t, 3 H, J=7.2 Hz ), 2.30 ( s, 3 H ), 3.77 ( s, 3 H ), 3.98 ( q, 2 H, J=7.2 Hz ), 4.65 ( s, 2 H ), 5.48 ( s, 2 H ), 6.23 ( s, 1 H ), 6.51 ( s, 1 H ), 7.11 ( m, 1 H ), 7.29～7.42 ( m, 1 H ), 7.89 ( s, 1 H ), 9.99 ( br s, 1 H ); Ⅷg: [MH+] (m/z): 596.4; 1H NMR: δppm: 1.06 (m, 2 H), 1.09 ( t, 3 H, J=7.1 Hz ), 1.24 ( m, 2 H ), 3.25 ( m, 1 H ), 被引量：1
Chinese Chemical Letters
2004年 第9期

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