摘要
目的：为进一步验证“复方效应成分动力学”假说提供临 床药物动力学(PK)研究依据。方法：用已建立的方法［１］，研究健康自 愿者一次口服川芎汤(1 g/kg)、川芎芍药(1∶1)汤(2 g/kg)后血清中阿魏酸(FA)的药动学。 结果：两组的血药时曲线均表现为双峰现象，属开放性一室模型。川芎汤和川芎芍药汤组 FA的主要药动学参数分别如下：Ka(L/min)=0.281 6±0.132 7 和0.120 6±0.062 1；Cmax(ng/mL)=100.084 4± 34.695 5和47.567 6±28.235 8;AUC(ng/min·mL)=15 734.88±7 063.77和5 717.92±5 590.99;Cl/F(s)(L/min)=0..002 8±0.001 4 和0.041 6±0.025 4;V/F(c)(ng/mL)=0.610 8±0.280 0和2.04 1 5±1.106 3。结论：川芎配伍芍药明显影响川芎在血清中FA的吸收、分布和排泄 等。
To provide further clinical pharmacokinetic evidenc e in support of the hypothesis “Phamacokinetic Effect of Compound Herbal Prescr iptions.” Healthy volunteers were given either a single oral dose (1 g/kg) of LW decoction or a single oral dose (2 g/kg) of LW and PV (1∶1) decoction, follo wed by the determination of serum ferulic acid (FA), one of the active principle in LW, as described in our previously published report［１］. Both group s gave serum FA concentrationtime curves with two peaks showing their open one compartment model nature. The main pharmacokinetic parameters of LW and LW+PV decoctions were: Ka(L/min)=0.281 6±0.132 7 and 0. 120 6±0.06 2 1； Cmax(ng/mL)=100.084 4±34.695 5 and 47.567 6±28 .235 8; AUC(ng/min·mL)=15 734.88±7 063.77 and 5 717.92±5 5 90.99; Cl/F(s)(L/min)=0.002 8±0.001 4 and 0.041 6±0.025 4 ; V/F(c)(ng/mL )=0.610 8±0.280 0 and 2.041 5±1.106 3. The above results indicated that PV coul d influence the absorption, distribution and elimination of FA when LW was presc r ibed in combination with PV. This provided an evidence in support of the hypoth esis of “Pharmacokinetic Effect of Compound Herbal Prescriptions”.
出处
《中草药》
CAS
CSCD
北大核心
2000年第12期915-917,共3页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目!(No.39870932
30070912)
高等学校骨干教师计划(教育部)
关键词
方剂配伍
临床药动学
川芎
川芎芍药汤
血药浓度
中医药疗法
Ligusticum wallichii Franch. decoction of Ligusticum wallichii and Paeonia veitchii Lynch blood drug concentration pharmacokinetics drug combination
