摘要
用ELISA法检测孕妇、子宫内膜异位症(EMT)、流产和不孕妇女血清中游离子宫内膜抗原(EMAg)和EMAg免疫复合物(EMAg-ICs)。结果:EMAg含量,孕妇组(n=63)为16.4±11.5(U/ml,(?)±s),EMT组(n=30)、流产组(n=37)和不孕组(n=48)分别为56.0±31.7、53.9±44.6和44.3±26.0U/ml;以≥40U/ml为阳性,3组患者EMAg阳性率分别为56.7％、32.4％和31.3％,均明显高于孕妇组(P<0.01)。孕妇组EMAg-ICs的水平((?)±s,U/ml)为0.33±0.09,阳性率为0;EMT组为0.71±0.28,阳性率73.3％,流产组为0.53±0.24,阳性率29.7％;不孕组为0.50±0.17,阳性率27.1％。提示EMAg-ICs可能参与对子宫内膜的免疫损害,且与流产、不孕有关。
Abstract Enzyme linked immunosorbent assay (ELISA) was used to detect free endometrial antigens (EMAg) and their immune complex (EMAg-ICs) in the serum of pregnancy, endometri-osis (EMT). abortive and infertile women. EMAg levels were 16.4 ±11.5 (U/ml, xis) in pregnant women (n = 63), 56.0131.7, 53.9±44.6 and 44.3±26.0 in EMT (n = 30), abortive (n = 37) and infertile (n = 48) patients, respectively. EMT was considered as positive when the level was 40 U/ml or higher. The positive rates of EMAg in three patient groups were 56.7%, 32.4% and 31.3%. respectively; they were all significantly higher than pregnant women group (0, P<0.01). The EMAg-ICs level (x±s) and its positive rate were 0.33±0.09 and 0% in pregnant women, 0.7110.08 and 73.3% in EMT group, 0.53±0.24 and 29.7% in abortive group, and 0.5010.17 and 27.1% in infertile group, respectively. It suggests that EMAg-ICs may play a role in immune injury of the endometrium, which may contribute to abortion and infertility.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1993年第1期30-32,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金
关键词
抗原
免疫复合物
子宫内膜异位
Endometrial antigen
Immune complex
Endometriosis
Infertility
