摘要
研究了创伤小鼠脾细胞白细胞介素-2(IL-2)的变化及其与抑制性T细胞(Ts)的关系。结果显示,创伤后IL-2产生减少,Ts数目增加,Ts活性增强,其中Ts活性与IL-2变化关系密切。创伤鼠脾细胞经去除Ts后,共IL-2生成能力恢复正常。提示创伤后Ts被激活,从而导致IL-2产生受抑。
The Change in interleukin-2 (IL-2) production of splenocyte and its relationship with suppressor T cell (Ts) were studied in mice after trauma. The results showed that IL-2 production was reduced, number of Ts was increased and activity of Ts correlated with reduced IL-2 production. Removal of Ts from splenocyte improved IL-2 production in traumatized mice. It is suggested that Ts is activated after trauma, resulting in impaired IL-2 production.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1993年第4期271-273,共3页
Medical Journal of Chinese People's Liberation Army
关键词
创伤
白细胞介素2
T细胞
Trauma
lnterleukin-2
Suppressor T cell