摘要
应用放射分析法测定355例肝病患者血清透明质酸(SHA)水平。结果:肝炎后肝硬化组(902±662μg/L)、血吸虫肝硬化组(469±512μg/L)、慢活肝组(477±309μg/L)、肝癌组(392±260μg/L)升高最为显著,其次为慢性血吸虫病组(202±184μg/L)、急性病毒性肝炎组(181±117μg/L)和慢迁肝组(91±64μg/L)。正常对照组SHA 值为63±40μg/L。表明SHA 是一项反映肝纤维化及其程度较好的临床生化指标,对病情判断、预后估价和药物疗效观察具一定的实用价值。
It has been known that hyaluronic acid(HA.)was mainly taken up anddegraded by the endothelial cells in liver sinusoids(LEC).Using RIA,serum levelsof HA were measured in 355 patients with various liver diseases.Levels of serum HAwas strikingly increased in cirrhosis related to viral hepatitis(902±662ug/l),late stageschistosomiasis(469±512ug/l),chronic active hapatitis(477±309ug/l),liver cancer(392±206ug/l),schistosomiasis of chronic stage(202±184ug/l), acute viral hepatitis(181±117ug/l).SHA of Chronic persistent hepatitis(91±64ug/l)has the value close to normal controls(63±40ug/l).Level of serum HA was significantly increased in fibrotic liver cirrhosis.Elevated concentration of HA could result from impaired LEC function,augmented bio-synthesis which enhanced release of HA,and portacarval shunting.
出处
《江苏医药》
CAS
CSCD
1993年第1期11-13,共3页
Jiangsu Medical Journal
