摘要
This study investigated the relationship between human papillomavirus (HPV) genotype and expression of p53and p21^(WAF1) Expression of p53 and p2l^(WAF1) in 35 cases ofcondyloma acuminatum specimens infected by HPV6/11andHPV16/18 were studied using immunohistochemical staining.All specimens of the condyloma acuminatum case were positivefor expression of p53 and p21^(WAF1). The expression of p53 incondyloma acuminatum infected by HPV16/18 wassignificantly lower than that in specimens infected byHPV6/11.However, expression of p21^(WAF1) between the twogroups was not significantly different. Expression of p53 incondyloma acuminatum is likely related to HPV genotype,exoression of p21^(WAF1) was not related to HPV genotype.
Abstract: This study investigated the relationship between human papillomavirus (HPV) genotype and expression of p53and p21^WAH1. Expression of p53 and p21^WAH1 in 35 cases of condyloma acuminatum specimens infected by HPV6/llandHPV16/18 were studied using immunohistochemical staining. All specimens of the condyloma acuminatum case were positivefor expression of p53 and p21^WAH1. The expression of p53 incondyloma acuminatum infected by HPV16/18 was significantly lower than that in specimens infected byHPV6/ll.However, expression of p21wAH between the twogroups was not significantly different. Expression of p53 incondyloma acuminatum is likely related to HPV genotype,expression of p21^WAH1 was not related to HPV genotype.
