摘要
目的了解江西省吉安市幼儿和育龄期妇女的风疹抗体水平及免疫后效果。方法接种风疹疫苗和采用风疹血凝抑制试验检测风疹血凝抗体(HI)。结果儿童和育龄妇女的自然感染率分别为5.19%和75.13%,接种风疹疫苗后无不良反应,儿童组抗体全部转为阳性,育龄妇女仅1例为阴性,几何平均滴度增高,接种疫苗后显著提升抗体水平。结论吉安市存在着较大数量的易感人群,有可能发生大规模的风疹流行,其中24.77%育龄妇女存在感染风疹导致CRS的可能;国产风疹病毒减毒株(BRDⅡ株)疫苗免疫原性效果较好,安全性高,适用于老区等经济相对落后的地方大范围内推广使用。吉安市防治风疹的免疫策略具体是,首先对1～14岁人群进行普及免疫,同时对育龄期妇女进行选择性免疫,随后将风疹的免疫纳入计划免疫管理。
Objective:Understand rubella antibody level and result after the immunity of the infant and women of chid-bearing age of JI'an of Jiangxi Province.Methods: Inoculate the rubella vaccine and adopt the rubella hemadsorption inhibition (HI)to measure its antibodies.Results: The natural infection rate of chidren and women of child-bearing age is respectively 5.19%and 75.13%。There is no bad reaction after inoculating the nettle rash vaccine.All Children group antibody transfer to positive, while women of child-bearing age has only one negative, and GMT increase, it is a positive antibody level to propose long notably after vaccine inoculation.Conclusion: There are more larger quantity of easily infected groups in Ji'an, it is prevailing that the extensive rubella may take place, among them 24.77%of the women of child-bearing age have possibility which is infected with CRS that the rubella causes.Domestic rubella strains of viruses(BRDⅡstain) have better immunity result, high security, which are suitable for widely using in the large range with relatively backward economy such as in old liberated area, etc.The immune tactics of preventing and curing rubella in Ji'an are concrete, popularize the immunity to the 1～14 years old crowd at first, carry on the alternative immunity to a woman of reproduction age at the same time, include the immunity of the rubella in the immunity of the plan to manage afterwards.
出处
《井冈山医专学报》
2004年第6期10-11,共2页
Journal of Jinggangshan Medical College
