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遗传性凝血因子Ⅺ缺陷的分子发病机制研究进展 被引量：4

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摘要 凝血因子Ⅺ(FⅪ)是血浆丝氨酸蛋白酶活化的凝血因子Ⅺ(FⅪa)的酶原,后者在钙离子存在时,可以活化FⅪ,形成活化的凝血因子Ⅺ(FⅪa).FⅪ由肝脏和巨核细胞所产生,人体内除血浆中存在有FⅪ外,血小板中也可能含有一部分FⅪ.
作者 武文漫 王鸿利
机构地区 上海第二医科大学附属瑞金医院上海血液学研究所
出处 《血栓与止血学》 2004年第4期181-184,共4页 Chinese Journal of Thrombosis and Hemostasis
关键词 遗传性凝血因子Ⅺ缺陷 分子发病机制 研究进展 基因突变
分类号 R552 [医药卫生—血液循环系统疾病]
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参考文献20

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同被引文献36

  • 1韩轩茂,任景芳,郝斌,曹文东,刘秀娥,侯丽虹,王学峰,丁秋兰,杨林花.静脉血栓栓塞患者凝血与抗凝血因子活性或含量的测定[J].中国药物与临床,2007,7(5):339-341. 被引量：2
  • 2Tapson VF, Carroll BA, Davidson BL, et al. The diagnostic approach to acute venous thromboembolism. Clinic practice guideline. American Thoracic Society[J]. Am J Respir Crit Care Med, 1999,160(3) : 1 043 -1 066. 被引量：1
  • 3Koster T, Rosendaal FR, Reitsma PH, et al. Factor Ⅶ and fibrinogen levels as risk factor for venous thrombosis. A case control study of plasma levels and DNA polymorphism. The leiden thrombophilia study. (LETS) [ J]. Thromb Haemost, 1994,71:719 - 722. 被引量：1
  • 4Vaya A, Mira Y, Martinez M, et al. Biological risk factors for deep vein thrombosis [ J ]. Clin Hemorheol Microcirc [ J ]. 2002,26 ( 1 ) :41 -53. 被引量：1
  • 5van Hylckama Vlieg A, van der Linden IK, Bertina RM, et al. High levels of factor Ⅸ increase the risk of venous thrombosis[ J]. Blood, 2000,95 (12) :3 678 -3 682. 被引量：1
  • 6Poort SR, Rosendaal FR, Reitsma PH, et al. A common genetic variation in the 39 - untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis[J]. Blood, 1996,88:3 698 -3 703. 被引量：1
  • 7Prandoni P, Noventa F, Ghirarduzzi A,et al. The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients [ J ]. Haematol, 2007,92 (2) :199 -205. 被引量：1
  • 8Redondo M, Watzke HH, Stucki B, et al. Coagulation factors Ⅱ, Ⅴ, Ⅶ, and Ⅹ, prothromhin gene 20210G→A transition, and factor Ⅴ Leiden in coronary artery disease: high factor Ⅴ clotting activity is and independent risk factor for myocardial infarction [ J ]. Arterioscler Thromb Vasc Biol, 1999,19 : 1 020 - 1 025. 被引量：1
  • 9Santamaria MG, Agnelli G, Taliani MR, et al. Thrombophilic abnormalities and recurrence of venous thromboembolism in patients treated with standardized anticoagulant treatment [ J ]. Thromb Res, 2005,116(4) :301 -6. 被引量：1
  • 10Girolami .4, Simioni P, Scaranol, et al. Symptomatic combined, homozygous factor Ⅻ deficiency and heterozygous factor Ⅴ Leiden [ J ]. Thromb Thrombolysis ,2000,9:271 - 275. 被引量：1

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血栓与止血学
2004年 第4期

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