摘要
目的 探讨反流性食管炎愈合后的长程治疗方案。方法 5 2例经胃镜检查证实食管炎病损已愈合患者。分为两组 :A组 2 6例为维持治疗组 ,奥美拉唑 10mgqd ,连用 6个月后 ,改为病人出现烧心、反酸、胸痛等胃食管反流病 (GERD)症状时 ,临时服奥美拉唑 10mg ;B组 2 6例为按需治疗组 ,患者出现烧心、反酸、胸痛等GERD症状时即服奥美拉唑 10mg。根据每个患者出现烧心、反酸、胸痛等症状的频度分为 :无症状 ;症状每月发生 ;症状每周发生 ;症状每天发生。分别在治疗期间的第 1、2、4、6、9、12月随访。结果 第1个月每天有反流症状的A组 4人 ,占本组总例数的 17% ,B组 15人 ,占本组总例数的 71% ;两组持续有反流症状的 7人 ,均是年龄偏大、食管炎偏重的患者。结论 反流性食管炎愈合后的长程治疗方案的选择主要根据病人的病情、患者出现症状的频率等因素而定。反流性食管炎较重的患者 (Ⅱ、Ⅲ级 ) ,需维持治疗 ;反流性食管炎较轻者 (Ⅰ级 ) 。
Objective To research a long term therapeutic scheme for patients with healed refluxing esophagitis Methods Fifty two cases of healed refluxing esophagitis confirmed by gastroscopy were recruited and divided into two groups Group A (26 cases) was treated with Omeprazole 10 mg,qd, for 6 months, and then 10 mg provisionally when some symptoms of gastroesophageal reflux disease such as heartburn, sour regurgitation, and chest pain arose Group B (26 cases) was given Omeprazole of 10mg only when some gastroesophageal reflux disease symptoms arose Effects of these treatments were evaluated with standard scores according to the symptoms and frequency of gastroesophageal reflux disease Patients were followed up during the 1 st , 2 nd , 4 th , 6 th , 9 th , 12 th month of treatment Results There were 4 and 17 cases in Group A and B respectively in which the refluxing symptoms occurred every day during the 1st month of treatment The symptoms lasted during the whole follow up period in 7 cases in the two groups Conclusion The long term treatment scheme for healed refluxing esophagitis depends on patients general condition and the refluxing frequency Long term treatment is necessary for severe refluxing esophagitis (Grade Ⅱ and Ⅲ), but for mild one (Grade Ⅰ) the treatment is provisional
出处
《实用医院临床杂志》
2004年第4期39-40,共2页
Practical Journal of Clinical Medicine
