摘要
目的 :观察枸橼酸莫沙必利治疗功能性消化不良的有效性和临床应用的安全性。方法 :采用双盲随机对照研究法。将 4 7例功能性消化不良患者随机分为 2组 :实验组 2 3例 ,其中男 14例 ,女 9例 ,年龄 (37.4± 14 .7)岁 ;对照组 2 4例 ,其中男 12例 ,女 12例 ,年龄 (33.8± 11.3)岁。实验组和对照组分别口服枸橼酸莫沙必利和西沙必利 5mg/次 ,3次 /d ,共治疗 4周。于治疗 14d、2 8d后评价疗效。结果 :实验组治疗 14d及 2 8d时早饱、上腹胀、上腹痛、恶心、呕吐、食欲不振、胃灼热、烧心、嗳气等症状有效率与对照组相比差异无统计学意义 (P >0 .0 5 )。 2组治疗 14d及 2 8d时胃排空率相比差异无统计学意义 (P >0 .0 5 )。在治疗过程中实验组 2例出现头晕 ,4例出现腹痛或腹泻 ,但均未影响继续治疗 ;对照组 1例因头晕中断治疗 ,3例出现腹痛或腹泻 ,未影响治疗。结论
Aim: To evaluate the clinical efficacy and safety of Mosapride treatment to functional dyspepsia. Methods: A total of 47 patients with functional dyspepsia were divided randomly into two group. Mosapride group of 23 patients was treated with Mosapride for 4 weeks, including 14 male and 9 female, aged (37.4±14.7) a. Cisapride group of 24 patients was treated with Cisapride for 4 weeks, including 12 male and 12 female, aged (33.8± 11.3) a. Results: The effective rates of Mosapride and Cisapride in treating early satiety,epigastric fullness,epigastric pain,nausea,vomit,decrease of food intake,pyrosis,heart burn, belch and symptom of the alimentary canal relief rate were not different when treated for 14 and 28 d (P>0.05).The rates of gastric emptying were not significant between 2 groups (P> 0.05). Four cases had diarrhea or bellyache and two cases had light headedness during the treatment of Mosapride group.Three cases had diarrhea or bellyache and one case had light headedness in Cisapride group. Conclusion: Mosapride is a new safe efficacious drug for treating functional dyspepsia.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2004年第6期1054-1056,共3页
Journal of Zhengzhou University(Medical Sciences)
