摘要
目的 探讨医院获得性肺炎克雷伯菌性肺炎患者体内的氧自由基损伤。方法 对呼吸加强病房 2 0例医院获得性肺炎克雷伯菌性肺炎患者血清脂质过氧化氢 ( L HP)水平、血清谷胱甘肽过氧化物酶 ( GSH- PX)及血清3种超氧化物歧化酶 ( SOD)进行测定 ,并与对照组进行比较。结果 克雷伯菌性肺炎组 L HP明显高于健康对照组 ,两组比较差异非常显著 ( t=7.890 1,P<0 .0 1) ;GSH- PX水平明显低于对照组 ,两组比较差异非常显著( t=9.9810 ,P<0 .0 1) ;SOD T、SOD Cu- Zn、SOD Mn水平明显低于对照组 ,两组比较差异非常显著 ( t=7.85 4 6 ,t=10 .3378,t=5 .2 179,均 P<0 .0 1)。结论 医院获得性肺炎克雷伯菌性肺炎患者体内存在由自由基介导的脂质过氧化损伤 ,这种脂质过氧化损伤参与了肺炎克雷伯菌性肺炎的病理过程 ;
OBJECTIVE To study the oxide damage effect of free radical in the patients with hospital acquired Klebsiella pneumoniae pneumonia. METHODS In 20 cases of patient group and 26 cases of control group, the activity of lipid hydroperoxides (LHP), glutathione peroxidase (GSH-PX) as well as three kinds of superoxide dismutase (SOD) in serum were detected and compared. RESULTS In serum, the activity of LHP, GSH-PX in patient group was higher than that of control one (P<0.01). Meanwhile the activity of three kinds of SOD in patient group was lower than in other one (P<0.01). CONCLUSIONS It shows that the peroxide damage is constantly going on in the cases of K. pneumoniae pneumonia, which joined into the injurious progress of ill. And it suggests that to use the drugs reducing free radicals improve the clinical effect.
出处
《中华医院感染学杂志》
CAS
CSCD
2004年第11期1207-1208,共2页
Chinese Journal of Nosocomiology
关键词
医院获得性感染
肺炎克雷伯菌
肺炎
自由基
Klebsiella pneumoniae pneumonia
Lipid hydroperoxides
Glutathione peroxidase
Superoxide dismutase
Free radical
