摘要
目的 :探讨氯胺铜对脓毒症大鼠血清肿瘤坏死因子 (TGF-α)、一氧化氮 (NO)的影响。方法 :应用盲肠结扎打孔法制作大鼠脓毒症模型 ,4 8只雄性 SD大鼠随机分为假手术组、脓毒症组、氯胺酮预防组、氯胺酮治疗组。术后 2 4 h检测血清 TGF-α、NO水平。结果 :氯胺酮组动物死亡率较脓毒症组低 (P<0 .0 5 ) ,血清 TGF-α、NO浓度降低 (P<0 .0 1) ,肠粘膜上皮炎症损伤程度均有减轻 (P<0 .0 5 )。结论 :氯胺酮对脓毒症肠粘膜屏障具有明显的保护作用。
Objective:To investigate the effect of ketamine on serum TNF-αand NO concentraion and the intestinal barrier in sepsis rats. Methods:Murine septic model was established through cecal ligation puncture(CLP). Ketamine was given to the septic rats to protective intestinal barrier disfunction. Blood was collected to examine serum TNF-αand NO concentraion.Results:Mortality rates in the prevention group and therapy group were significantly lower than that in the septic group(P<0.05). Serum TNF-αand NO concentration were significantly lower in the prevention group and therapy group(P<0.01). The degree of inflammatory injury of intestinal mucosa was much milder in the prevention group and therapy group than those in the septic group(P<0.05).Conclusion:Ketamine could protect the intestinal mucosa barriers and improve the prognosis of sepsis.
出处
《中国误诊学杂志》
CAS
2004年第7期990-991,共2页
Chinese Journal of Misdiagnostics
