摘要
为探讨卡维地洛对冠心病患者经皮腔内冠状动脉成形术后血中内皮素及一氧化氮的影响 ,本文选择经冠状动脉造影证实有一支或二支以上≥ 70 %狭窄需行经皮腔内冠状动脉成形术的患者 5 1例 ,随机分成卡维地洛组2 8例和常规治疗组 2 3例 ,测定经皮腔内冠状动脉成形术前后及用药前后外周血内皮素及一氧化氮含量。结果发现 ,经皮腔内冠状动脉成形术后血中内皮素 (卡维地洛组为 84 .9± 14 .7μg/L、常规治疗组为 85 .6± 15 .4 μg/L)较术前 (卡维地洛组为 70 .6± 12 .8μg/L、常规治疗组为 71.5± 13.3μg/L)增高 ;一氧化氮 (卡维地洛组为 5 0 .3± 13.4μmol/L、常规治疗组为 5 0 .9± 12 .6 μmol/L)较术前 (卡维地洛组为 6 2 .9± 14 .2 μmol/L、常规治疗组为 6 3.5± 13.1μmol/L)降低 (P <0 .0 5 ) ;卡维地洛组内皮素为 74 .6± 15 .6 μg/L ,较用药前 (84 .4± 14 .9μg/L)降低 ;一氧化氮为 6 2 .7± 12 .8μmol/L ,较用药前 (5 1.6± 12 .5 μmol/L)增高 (P <0 .0 5 ) ,常规治疗组内皮素和一氧化氮观察两周均无显著变化 (P >0 .0 5 )。
Aim To understand the effect of carvedilol on the coronary vascular endothelial function of the patients with coronary heart disease after percutaneous transluminal coronary angioplasty (PTCA). Methods 51 cases,having one or more than two branches narrow (≥70%),were diagnosed by coronary angiography. These patients were divided randomly into carvedilol group (n=28) and control group (n=23) who did not take carvedilol. Endothelin (ET) and nitric oxide (NO) levels of peripheral blood were measured before and after PTCA,before and after two week by taking carvedilol. Results Compared with the ET (carvedilol group: 70.6±12.8 μg/L,control group: 71.5±13.3 μg/L) and NO (carvedilol group: 50.3±13.4 μmol/L,control group: 50.9±12.6 μmol/L) levels before PTCA,ET (carvedilol group: 84.9±14.7 μg/L,control group: 85.6±15.4 μg/L) were markedly increased and NO (carvedilol group: 50.3±13.4 μmol/L,control group: 50.9±12.6 μmol/L) were decreased after PTCA (P<0.05); compared with the ET (84.4±14.9 μg/L) and NO (51.6±12.5 μmol/L) levels before taking carvedilol,ET (74.6±15.6 μg/L) were decreased and NO (62.7±12.8 μmol/L)were increased after two weeks (P<0.05),but the ET and NO levels of the control group did not change in the period of two-week observation (P>0.05). Conclusion Carvedilol may improve the coronary vascular endothelial function after PTCA.
出处
《中国动脉硬化杂志》
CAS
CSCD
2004年第5期599-601,共3页
Chinese Journal of Arteriosclerosis
