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survivin与宫颈癌 被引量:1

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摘要 survivin是新近发现的一种肿瘤特异性凋亡抑制基因,其在正常成人终末分化组织基本不表达或低表达,而在胚胎和几乎所有肿瘤组织中高表达,具有抑制细胞凋亡、调节细胞周期分化及参与血管形成的作用。survivin的表达与癌变关系密切,在宫颈癌及其癌前病变中,survivinmRNA表达上调,并与临床分期、组织学分级及预后有关,且与高危型HPV感染密切相关。survivin与肿瘤细胞耐药性有关,可作为一个新的肿瘤诊断和治疗的靶基因。
出处 《国外医学(妇产科学分册)》 CAS 2004年第5期317-319,共3页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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