摘要
目的 :探讨羟基喜树碱 +顺铂 +5 氟脲嘧啶化疗方案联合放疗治疗中晚期鼻咽癌的价值。方法 :117例经病理学检查确诊的鼻咽癌患者随机分为HPF组和PF组。HPF组 6 0例 ,用羟基喜树碱 16mg/m2 静滴 ,d1,3 天 ;顺铂 5 0～ 6 0mg/m2 ,静滴 ,d1;5 氟脲嘧啶 5 0 0mg/m2 静滴 ,d1～ 5。PF组 5 7例 ,顺铂 5 0～ 6 0mg/m2 ,静滴 ,d1;5 氟脲嘧啶 5 0 0mg/m2 静滴 ,d1～ 5。 2 1天为 1周期 ,共 2～ 4周期 ,两组均同时进行放疗 ,鼻咽及颈部病灶 :DT 6 0～ 70Gy/ 6～ 7w。颈部预防量 :DT 5 0Gy/5w。结果 :HPF组CR 6例 ,PR 2 7例 ,总有效率 (CR +PR) 5 5 6 %。PF组CR 4例 ,PR 2 3例 ,总有效率 4 7 36 %。中位进展时间HPF组 18个月 ,PF组 16个月。 1年和 3年生存率HPF组为 84 78%和 74 5 % ,PF组为 82 4 6 %和 72 34%。两组Ⅲ度以上的毒副反应小 ,主要为口腔溃疡、恶心呕吐、白细胞减少。结论 :羟基喜树碱 +顺铂 +5 氟脲嘧啶化疗联合放疗是治疗中晚期鼻咽癌疗效较高 ,毒副反应较小的方法之一。
Objective:To observe the therapeutic effects of Hydroxycamptothecin (HCPT) combined with usual used chemtherapy and radiotherapy for advanced Nasopharyngal carcinoma.Methods:117 patients with advanced Nasopharyngal carcinoma were treated from Jun.1999 to Jun. 2002. These patients were randomized into two groups. HPF(FCPT+PDD+5-FU)60 cases,HCPT 16 mg/m2 ivgtt, d 1,3 ,PDD 50～60 mg/m2,ivgtt, d 1,5-FU 500 mg/m2 ivgtt,d 1～5 . PF(PDD+5-FU)57 cases, PDD 50～60 mg/m2, ivgtt, d 1,5-FU 500 mg/2,ivgtt, d 1～5 , 21days was taken as a cycle of treatment. All the patients completed two～four cycle treatment, All the patients completed usual radiotherapy. DT 60～70Gy/6～7W.Results:HPF group CR 6%,PR 27%.RR(CR+PR) 55.6%.PF group CR 4%, PR 23%, RR 47.36%. Median time pregression (mTTP) HPF 18 months, PF 16 months. 1、3 years survival rate HPF 84.74%、74.5%, PF 82.46%、72.34%. Grade Ⅲtoxicities of HPF included stomatitis 2%, nausea and vomiting 3% and leukopenic 3%.Conclusion:The HPF chemotherapy and radiotherapy could be well tolerated for patients with advanced Nasopharyngal carcinoma. The immediate response was encouraging.
出处
《临床肿瘤学杂志》
CAS
2004年第5期464-465,468,共3页
Chinese Clinical Oncology
