摘要
目的 :观察国产去甲长春花碱 (盖诺 )联合顺铂序贯放疗治疗局部晚期非小细胞肺癌的疗效和不良反应。方法 :31例Ⅲ期非小细胞肺癌首先接受NP方案化疗 ,即 :盖诺 2 5mg/m2 ,d1、d8,顺铂 2 5mg/m2 ,d1～ 3,2 1天为 1个周期 ,至少 3个周期化疗后又随机分为常规放疗组 (A组 )及常规放疗加分次立体定向放疗组 (B组 )。结果 :化疗总有效率 4 5 1% ,化疗 +放疗总有效率 6 7 7%。A和B组有效率分别为 5 0 0 % (8/16 )和 86 6 % (13/15 ) (P <0 0 5 ) ;1年生存率分别为 5 6 2 % (9/16 )和 6 6 6 % (10 /15 ) ;中位生存期 (MST)各为 13 2和 16个月 ;中位疾病进展时间 (TTP)各为 7 1个月和 8 3个月。全组毒副反应有白细胞减少、贫血、静脉炎、食管炎和肺炎。结论 :NP方案序贯放疗治疗局部晚期非小细胞肺癌疗效明显 ,耐受性好。
Objective:To evaluate the effect and adverse event of sequential thora radiotherapy in combination with cisplatin and homemade vinorelbine in locally advanced non-small-cell lung cancer.Methods:31 cases received vinorelbine 25mg/m2 on d1,d8 and cisplatin 25mg/m2 on d1-d3 combination chemotherapy.Each cycle consists of 21 days with at least 3 cycles administered for one course.They were randomly divided into two groups:Concomitant radiotherapy(Group A) and concomitant radiotherapy plus fractional stereotacitic radiotherapy(Group B).Results:The overall response rates were 45.1% in chemotherapy alone and 67.7% in chemotherapy plus radiotherapy.The response rate of group A and B was 50.0% and 86.6%,respectively.The 1-year survival time were 56.2% for group A and 66.6% for group B.The median survival duration were 13.2 and 16 months for group A and B.The Median time to progression were 7.1 and 8.3 months for group A and group B.The main side-effects were leucopenia,anemia,phlebitis,esophagitis and pneumonitis.Conclusion:The NP regimen plus sequential radiotherapy is rather active for locally advanced non-small-cell lung cancer with acceptable tolerance.
出处
《临床肿瘤学杂志》
CAS
2004年第5期459-460,463,共3页
Chinese Clinical Oncology
