摘要
目的 观察乌司他丁对休克患者肾功能的保护作用。方法 入选 2 8例休克患者随机分为乌司他丁治疗组和对照组 ,治疗组在常规抗休克治疗的同时给乌司他丁 2 0万U ,加入生理盐水 10 0ml,q8h静滴 ;对照组常规抗休克治疗 ,方案与观察组相同。观察两组的尿量、肾功能恢复情况。结果 与对照组比较 ,治疗组尿量明显增加 ,尿NAG(N 乙酰 β 氨基葡萄糖苷酶 )、α1 微球蛋白明显减少 ,血BUN和Scr明显低于对照组。治疗组患者在观察期间需要行持续肾脏替代治疗的百分率为 14 2 8% ,明显低于对照组的 5 7 14 %。结论 乌司他丁具有保护肾小管功能及促进休克患者肾功能恢复的作用。
Objective To investigate the protective influence of ulnastatin on renal function in patients with shock.Methods 28 selected cases were randomized divided into 2 subgroups(14 cases is each).The observed group were accepted anti-shock methods in addition to high dose of ulnastatin while the control group were only with anti-shock therapy.The urine volume and the renal functions were investigated before and after treatment of all patients.Results There was more urine in the observed group than that in the control one.The NAG(β-N-acetyglocosamidase) and α 1-M(α 1-microglobulin) contained in patients' urine of the observed group were less than those of the control one.The BUN and Cr in patients' serum of the observed group were less than those of the control one.The rate who needed for CRRT(continuous renal replacement therapy) of the observed group were lower than that of the control one.Conclusion When patients fell down with shock,ulnastatin is very effective on protecting tubular of kidneys and promote the recovery from renal failure.
出处
《中国基层医药》
CAS
2004年第8期932-933,共2页
Chinese Journal of Primary Medicine and Pharmacy
